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Letters to Nature
Nature 380, 152 - 154 (14 March 1996); doi:10.1038/380152a0

A comprehensive genetic map of the human genome based on 5,264 microsatellites

Colette Dib*, Sabine Fauré*, Cécile Fizames*, Delphine Samson*, Nathalie Drouot*, Alain Vignal*, Philippe Millasseau*, Sophie Marc*, Jamile Kazan*, Eric Seboun*, Mark Lathrop, Gabor Gyapay*, Jean Morissette* & Jean Weissenbach*§

*Génethon and CNRS URA 1922, 1 rue de I'Internationale, 91000 Evry, France
INSERM U358, Hôpital Saint-Louis, Paris, France
Centre de Recherche du Centre Hospitalier de I'Université Laval, Québec G1V 4G2, Canada
§To whom correspondence should be addressed

THE great increase in successful linkage studies in a number of higher eukaryotes during recent years has essentially resulted from major improvements in reference genetic linkage maps1–6, which at present consist of short tandem repeat polymorphisms of simple sequences or microsatellites7,8. We report here the last version of the Généthon human linkage map6. This map consists of 5,264 short tandem (AC/TG)n repeat polymorphisms with a mean heterozygosity of 70%. The map spans a sex-averaged genetic distance of 3,699 cM and comprises 2,335 positions, of which 2,032 could be ordered with an odds ratio of at least 1,000:1 against alternative orders. The average interval size is 1.6 cM; 59% of the map is covered by intervals of 2 cM at most and 1% remains in intervals above 10 cM.

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