Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity

Nature volume 372, pages 150–157 (1994)Cite this article

A Retraction to this article was published on 03 July 2013

Abstract

THIS PAPER HAS BEEN RETRACTED; see retraction.

A diversity of high-affinity Oligosaccharide ligands are identified for NKR-P1, a membrane protein on natural killer (NK) cells which contains an extracellular Ca2+-dependent lectin domain. Interactions of such oligosaccharides on the target cell surface with NKR-P1 on the killer cell surface are crucial both for target cell recognition and for delivery of stimulatory or inhibitory signals linked to the NK cytolytic machinery. NK-resistant tumour cells are rendered susceptible by preincubation with liposomes expressing NKR-P1 ligands, suggesting that purging of tumour or virally infected cells in vivo may be a therapeutic possibility.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Feizi, T. Nature 314, 53–57 (1985).

    Article  ADS  CAS  Google Scholar 

  2. Hakomori, S. Cancer Res. 45, 2405–2414 (1985).

    CAS  PubMed  Google Scholar 

  3. Feizi, T. & Childs, R. A. Biochem. J. 245, 1–11 (1987).

    Article  CAS  Google Scholar 

  4. Feizi, T. in Carbohydrate Recognition in Cellular Function Ciba Found. Symp. 145 (eds Bock, G. & Harnett, S.) 62–79 (Wiley, Chichester, 1989).

    Google Scholar 

  5. Drickamer, K. Curr. Opin. struct. Biol. 3, 393–400 (1993).

    Article  CAS  Google Scholar 

  6. Feizi, T. Curr. Opin. struct. Biol. 3, 701–710 (1993).

    Article  CAS  Google Scholar 

  7. Bevilacqua, M. P. & Nelson, R. M. J. clin. Invest. 91, 379–387 (1993).

    Article  CAS  Google Scholar 

  8. Lasky, L. A. et al. Cell 56, 1045–1055 (1989).

    Article  CAS  Google Scholar 

  9. McEver, R. P. J. Cell Biochem. 45, 156–161 (1991).

    Article  CAS  Google Scholar 

  10. Chambers, W. H., Adamkiewicz, T. & Houchins, J. P. Glycobiology 3, 9–14 (1993).

    Article  CAS  Google Scholar 

  11. Yokoyama, W. M. Curr. Opin. Immun. 5, 67–73 (1993).

    Article  CAS  Google Scholar 

  12. Trinchieri, G. Adv. Immun. 47, 187–376 (1989).

    Article  CAS  Google Scholar 

  13. Giorda, R. et al. Science 249, 1298–1300 (1990).

    Article  ADS  CAS  Google Scholar 

  14. Ryan, J. C., Turck, J., Niemi, E. C., Yokoyama, W. M. & Seaman, W. E. J. Immun. 149, 1631–1635 (1992).

    CAS  PubMed  Google Scholar 

  15. Yokoyama, W. M. & Seaman, W. E. A. Rev. Immun. 11, 613–635 (1993).

    Article  CAS  Google Scholar 

  16. Chambers, W. H. et al. J. exp. Med. 169, 1373–1389 (1989).

    Article  CAS  Google Scholar 

  17. Ryan, J. C., Niemi, E. C., Goldfien, R. D., Hiserodt, J. C. & Seaman, W. E. J. Immun. 147, 3244–3250 (1991).

    CAS  PubMed  Google Scholar 

  18. Bezouška, K. et al. J. biol. Chem. 269, 16945–16952 (1994).

    PubMed  Google Scholar 

  19. Kjellen, L. & Lindahl, U. A. Rev. Biochem. 60, 443–475 (1991).

    Article  CAS  Google Scholar 

  20. Scudder, P. et al. Eur. J. Biochem. 157, 365–373 (1986).

    Article  CAS  Google Scholar 

  21. Karlhofer, F. M., Ribaudo, R. K. & Yokoyama, W. M. Nature 358, 66–70 (1992).

    Article  ADS  CAS  Google Scholar 

  22. Ryan, J. C., Niemi, E. C. & Seaman, W. E. Nat. Immun. Cell Growth Reg. 11, 279 (abstr.) (1992).

    Google Scholar 

  23. McCoy, J. P. Jr & Chambers, W. H. Glycobiology 1, 321–328 (1991).

    Article  CAS  Google Scholar 

  24. Ando, I. et al. Int. J. Cancer 40, 12–17 (1987).

    Article  CAS  Google Scholar 

  25. Grayson, G. & Ladisch, S. Cell. Immun. 139, 18–29 (1992).

    Article  CAS  Google Scholar 

  26. Yamamoto, H., Fuyama, S., Arai, S. & Sendo, F. Cell. Immun. 96, 409–417 (1985).

    Article  CAS  Google Scholar 

  27. Yogeeswaran, G. et al. Int. J. Cancer 28, 517–526 (1981).

    Article  CAS  Google Scholar 

  28. Young, W. M. Jr, Durdik, J. M., Urdal, D., Hakomori, S. & Henney, C. S. J. Immun. 126, 1–6 (1981).

    CAS  PubMed  Google Scholar 

  29. Forbes, J. T., Bretthauer, R. K. & Oeltmann, T. N. Proc. natn. Acad. Sci. U.S.A. 78, 5797–5801 (1981).

    Article  ADS  CAS  Google Scholar 

  30. Chambers, W. H. & Oeltmann, T. N. J. Immun. 137, 1469–1474 (1986).

    CAS  PubMed  Google Scholar 

  31. Haubeck, H.-D., Kolsch, E., Imort, M., Hasilik, A. & von Figura, K. J. Immun. 134, 65–69 (1985).

    CAS  PubMed  Google Scholar 

  32. von Figura, K. & Hasilik, A. A. Rev. Biochem. 55, 167–193 (1986).

    Article  CAS  Google Scholar 

  33. Young, W. W. Jr, Hakomori, S., Durdik, J. M. & Henney, C. S. J. Immun. 124, 199–201 (1980).

    CAS  PubMed  Google Scholar 

  34. Chou, D. K. H. et al. J. biol. Chem. 261, 11717–11725 (1986).

    CAS  PubMed  Google Scholar 

  35. Ohmori, K. et al. Blood 74, 255–261 (1989).

    CAS  PubMed  Google Scholar 

  36. Stoll, M. S., Mizuochi, T., Childs, R. A. & Feizi, T. Biochem. J. 256, 661–664 (1988).

    Article  CAS  Google Scholar 

  37. Gooi, H. C. et al. J. biol. Chem. 260, 13218–13224 (1985).

    CAS  PubMed  Google Scholar 

  38. Larkin, M. et al. J. biol. Chem. 267, 13661–13668 (1992).

    CAS  PubMed  Google Scholar 

  39. Yuen, C.-T, et al. J. biol. Chem. 269, 1595–1598 (1994).

    CAS  PubMed  Google Scholar 

  40. Loveless, R. W., Floyd-O'Sullivan, G., Raynes, J. G., Yuen, C.-T. & Feizi, T. EMBO J. 11, 813–819 (1992).

    Article  CAS  Google Scholar 

  41. Schwarzmann, G. & Sandhoff, K. Meth. Enzym. 138, 319–341 (1987).

    Article  CAS  Google Scholar 

  42. Feizi, T., Stoll, M. S., Yuen, C.-T., Chai, W. & Lawson, A. M. Meth. Enzym. 230, 484–519 (1993).

    Article  Google Scholar 

  43. Vujanovic, N. L., Herberman, R. B., Maghazachi, A. A. & Hiserodt, J. C. J. exp. Med. 167, 15–29 (1988).

    Article  CAS  Google Scholar 

  44. Ward, J. M. & Reynolds, C. W. Am. J. Path. 111, 1–10 (1983).

    CAS  PubMed  Google Scholar 

  45. Brunner, K. T., Manuel, J., Cerottini, J. C. & Chapuis, B. Immunology 14, 181–196 (1968).

    CAS  PubMed  PubMed Central  Google Scholar 

  46. Feizi, T., Childs, R. A., Watanabe, K. & Hakomori, S. J. exp. Med. 149, 975–980 (1979).

    Article  CAS  Google Scholar 

  47. Chused, T. M. et al. Cytometry 8, 396–404 (1987).

    Article  CAS  Google Scholar 

  48. Robinson, P. J. in Immunological Methods Vol. III (eds Lefkovitz, I. & Pernis, B.) 125–132 (Academic, Orlando, 1979).

    Google Scholar 

  49. Laemmli, U. K. Nature 227, 680–685 (1970).

    Article  ADS  CAS  Google Scholar 

  50. Ebel, F., Schmitt, E., Peter-Katalinic, J., Kniep, B. & Mühlradt, P. F. Biochemistry 31, 12190–12197 (1992).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Glycobiology, The Glycosciences Laboratory, Northwick Park Hospital, Watford Road, Harrow, Middlesex, HA1 3UJ, UK

    Karel Bezouška, Chun-Ting Yuen, Jacqui O'Brien, Robert A. Childs & Ten Feizi

  2. Mass Spectrometry Groups, The Glycosciences Laboratory, Northwick Park Hospital, Watford Road, Harrow, Middlesex, HA1 3UJ, UK

    Wengang Chai & Alexander M. Lawson

  3. Department of Biochemistry, Faculty of Science, Charles University Prague, Hlavova 8, CZ-12840, Praha, 2, Czech Republic

    Karel Bezouška

  4. Department of Immunology and Gnotobiology, Institute of Microbiology, Czech Academy of Sciences, Videftska 1083, CZ-14220, Praha, 4, Czech Republic

    Karel Drbal, Anna Fišerová & Miloslav Posíšil

Authors
  1. Karel Bezouška
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chun-Ting Yuen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jacqui O'Brien
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Robert A. Childs
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Wengang Chai
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Alexander M. Lawson
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Karel Drbal
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Anna Fišerová
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Miloslav Posíšil
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Ten Feizi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bezouška, K., Yuen, CT., O'Brien, J. et al. Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity. Nature 372, 150–157 (1994). https://doi.org/10.1038/372150a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/372150a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing