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Letters to Nature

Nature 369, 648-652 (23 June 1994) | doi:10.1038/369648a0; Received 22 December 1993; Accepted 6 April 1994

Cytotoxic T-cell memory without antigen

Lisa. L. Lau, Beth D. Jamieson, T. Somasundaram & Rafi Ahmed*

  1. Department of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, California 90024, USA
  2. * To whom correspondence should be addressed
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MEMORY is a hallmark of the immune system and ever since its recognition there has been considerable interest in understanding how immunity is maintained1–5. The current model is that long-term memory is dependent on persistent antigenic stimulation6–11. We report here results that challenge this view and provide evidence that antigen is not essential for the maintenance of CD8+ T-cell memory. We show that memory CD8+ cytotoxic T lymphocytes persist indefinitely in the absence of priming antigen, retain the memory phenotype (CD44hi), and provide protection against virus challenge. These findings suggest a re-evaluation of our current thinking on mechanisms involved in maintaining immunity and have implications towards designing effective vaccination strategies.