| | Opinion |  |
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| | The last regional particle accelerator? 507
Next week's meeting of the CERN Council will not, after all, provide the full-throated endorsement of the Large Hadron Collider for which physicists had been hoping. But cautious governments should restrain misanthropy.
doi:10.1038/369507a0
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Nature bimonthly index 507
doi:10.1038/369507b0
PDF (311K)
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| | US health reform falters 508
The US Congress is in bitter dispute about health reform and the proposed employer mandates.
doi:10.1038/369508a0
PDF (136K)
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| | ... and in Britain also 508
Britain's internal market in health care has made problems for research.
doi:10.1038/369508b0
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| | News | |
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| | UK and Germany put the squeeze on CERN's plans for new accelerator 509
Alison Abbott
doi:10.1038/369509a0
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| | ... as Spain gets cut-rate membership 509
Alison Abbott
doi:10.1038/369509b0
PDF (332K)
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| | IBM physicist picked for Trieste centre 510
doi:10.1038/369510a0
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| | US physicists urged to build links with the modern world 510
Colin Macilwain
doi:10.1038/369510b0
PDF (157K)
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| | Budget freeze taints French science plans 511
Declan Butler
doi:10.1038/369511a0
PDF (143K)
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| | Soap giants trade blows over tests 511
Maggie Verrall
doi:10.1038/369511b0
PDF (143K)
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| | Italian researchers in bid for fairer promotion rules 512
Alison Abbott
doi:10.1038/369512a0
PDF (147K)
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| | US science to pay price if station proceeds 512
Colin Macilwain
doi:10.1038/369512b0
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| | Canada cuts role in space station, but boosts overall plans 512
David Spurgeon
doi:10.1038/369512c0
PDF (147K)
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| | 'Misconduct' definitions still prove elusive 513
Barbara J. Culliton
doi:10.1038/369513a0
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| | ESO seeks new promises from Chile 513
Alun Anderson
doi:10.1038/369513b0
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| | Tensions grow over health research proposals 514
David Dickson
doi:10.1038/369514a0
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| | Biomedical levy gathers pace in US 514
Colin Macilwain
doi:10.1038/369514b0
PDF (410K)
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| | Breast cancer prevention trials 'can re-start' 515
Helen Gavaghan
doi:10.1038/369515a0
PDF (157K)
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| | Japan signs co-operation agreement with UK 515
David Swinbanks
doi:10.1038/369515b0
PDF (157K)
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| | Correspondence | |
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| | Why use BST? 516
Verner Paetkau
doi:10.1038/369516a0
PDF (134K)
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Quis custodiet?
516
Tommaso Todisco
doi:10.1038/369516b0
PDF (134K)
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| | Nuclear weapons 516
Janet Bloomfield
doi:10.1038/369516c0
PDF (134K)
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| | Rough justice 516
John C. Marshall & Jennifer M. Gurd
doi:10.1038/369516d0
PDF (134K)
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| | News and Views |  |
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| | Cocktail party effect made tolerable 517
Disentangling meaningful signals from a background of otherwise distracting noise is a commonly practised skill, now shown to be mathematically feasible and even a basis for building neural networks to do the job.
John Maddox
doi:10.1038/369517a0
PDF (153K)
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| | Drowned trees record dry spells 518
F. Alayne Street-Perrott
doi:10.1038/369518a0
References | PDF (179K)
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| | Thrombopoietin — at last 519
Donald Metcalf
doi:10.1038/369519a0
References | PDF (348K)
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| | p21 inhibits cyclin shock 520
Jonathon Pines
doi:10.1038/369520a0
References | PDF (319K)
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| | Much ado about something 521
Douglas Richstone
doi:
PDF (265K)
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| | The new treasure seekers 522
Anthony E. Fallick
doi:10.1038/369522a0
References | PDF (444K)
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| | The essential twist 523
Ronny Drapkin & Danny Reinberg
doi:10.1038/369523a0
References | PDF (451K)
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| | Lagging ahead 524
David Jones
doi:10.1038/369524a0
PDF (150K)
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| | Scientific Correspondence | |
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| | fMRI of human visual cortex 525
Stephen A. Engel, David E. Rumelhart, Brian A. Wandell, Adrian T. Lee, Gary H. Glover, Eduardo-Jose Chichilnisky & Michael N. Shadlen
doi:10.1038/369525a0
References | PDF (169K)
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| | Origin of introns−early or late? 526
John M. Logsdon Jr & Jeffrey D. Palmer
doi:10.1038/369526a0
References | PDF (129K)
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| | Origin of introns−early or late? 526
Arlin Stoltzfus
doi:10.1038/369526b0
References | PDF (252K)
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| | Origin of introns−early or late? 527
Rüdiger Cerff, William Martin & Henner Brinkmann
doi:10.1038/369527a0
References | PDF (263K)
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| | Can female adders multiply? 528
Massimo Capula & Luca Luiselli
doi:10.1038/369528a0
References | PDF (141K)
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| | Can female adders multiply? 528
Mats Olsson, Annica Gullberg, Håkan Tegelström, Thomas Madsen & Richard Shine
doi:10.1038/369528b0
References | PDF (142K)
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| | Book Reviews |  |
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| | The essence of emergence 529
Michael Berry reviews The Quark and the Jaguar: Adventures in the Simple and the Complex
By
Murray Gell-Mann
doi:10.1038/369529a0
PDF (158K)
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| | The land of the Incas 529
doi:10.1038/369529b0
PDF (158K)
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| | Science at bay 530
Bob Johnstone reviews Science Has No National Borders: Harry C. Kelly and the Reconstruction of Science in Postwar Japan
By
Hideo Yoshikawa & Joanne Kauffman
doi:10.1038/369530a0
PDF (161K)
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| | Better late than never 531
Paul Bahn reviews Timewalkers: The Prehistory of Global Colonization
By
Clive Gamble
doi:10.1038/369531a0
PDF (305K)
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| | Coccolithophores 531
doi:10.1038/369531b0
PDF (186K)
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| | Picturing mathematical information 532
Nick Beard reviews The Visual Mind: Art and Mathematics
Edited by
Michele Emmer
doi:10.1038/369532a0
PDF (136K)
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| | Article |  |
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| | Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand 533
Physiological platelet synthesis is thought to require the humoral activities of meg-CSF and thrombopoietin, which respectively promote proliferation and maturation of megakaryocytic cells. A meg-CSF/thrombopoietin-like protein that is present in plasma of irradiated pigs has been purified and cloned. This protein binds to and activates the c-mpl protein, a member of the cytokine receptor superfamily. The isolated Mpl ligand shares homology with erythropoietin and stimulates both megakaryocytopoiesis and thrombopoiesis.
Frederic J. de Sauvage, Philip E. Hass, Susan D. Spencer, Beth E. Malloy, Austin L. Gurney, Steven A. Spencer, Walter C. Darbonne, William J. Henzel, Suzy C. Wong, Wun-Jing Kuang, Karl J. Oles, Bruce Hultgren, Lawrence A. Solberg Jr, David V. Goeddel & Dan L. Eaton
doi:10.1038/369533a0
References | PDF (697K)
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| | Letters | |
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| | Dust formation in Nova Cassiopeiae 1993 seen by ultraviolet absorption 539
S. N. Shore, S. Starrffield, R. Gonzalez-Riestrat, P. H. Hauschildt & G. Sonneborn
doi:10.1038/369539a0
First paragraph & References | PDF (363K)
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| | Optical measurements of the superconducting gap in single-crystal K3C60 and Rb3C60
541
L. Degiorgi, G. Briceno, M. S. Fuhrer, A. Zettl & P. Wachter
doi:10.1038/369541a0
First paragraph & References | PDF (317K)
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| | Zeolite-encapsulated Mn(II) complexes as catalysts for selective alkene oxidation 543
COMPLEXES of manganese(ii) with bipyridine (bpy) have the potential to act as catalysts for oxidation of alkanes and alkenes when the complex is oxidized in acidic conditions1−6. But their catalytic activity in solution is limited by their catalase activity7—their tendency to decompose H2O2. Because of their polynuclear nature such complexes cannot induce epoxidation of alkenes, and other epoxidation catalysts suffer from self-oxidation and side reactions8−11. Moreover, all of these homogeneous catalytic processes require phase-transfer conditions. Here we report that, when encapsulated in the supercages of zeolites X and Y, cis-[Mn(bpy)2]2+ complexes can catalyse selective epoxidation of alkenes without complications from competing processes such as self-oxidation or catalase activity. Epoxidation of cycloalkenes is followed by acid-catalysed ring-opening, carbon−carbon bond cleavage and formation of alkenedioic acids (Fig. 1). All of the various intermediates in the process can be obtained selectively by controlling the reaction conditions and zeolite acidity. Thus this supramolecular system provides a clean, one-step heterogeneous catalytic route to useful industrial products.
Peter-Paul Knops-Gerrits, Dirk De Vos, Frédéric Thibault-Starzyk & Pierre A. Jacobs
doi:10.1038/369543a0
References | PDF (466K)
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| | Extreme and persistent drought in California and Patagonia during mediaeval time 546
Scott Stine
doi:10.1038/369546a0
First paragraph & References | PDF (470K)
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| | Rapid cycling of high-molecular-weight dissolved organic matter in the ocean 549
Rainer M. W. Amon & Ronald Benner
doi:10.1038/369549a0
First paragraph & References | PDF (521K)
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| | Formation of the Muzo hydrothermal emerald deposit in Colombia 552
T. L. Ottaway, F. J. Wicks, L. T. Bryndzia, T. K. Kyser & E. T. C. Spooner
doi:10.1038/369552a0
First paragraph & References | PDF (453K)
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| | Bilateral hand representation in the postcentral somatosensory cortex 554
Yoshiaki Iwamura, Atsushi Iriki & Michio Tanaka
doi:10.1038/369554a0
First paragraph & References | PDF (349K)
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| | Excitation-contraction uncoupling and muscular degeneration in mice lacking functional skeletal muscle ryanodine-receptor gene 556
Hiroshi Takeshima, Masamitsu lino, Hiroaki Takekura, Miyuki Nishi, Junko Kuno, Osamu Minowa, Hiroshi Takano & Tetsuo Noda
doi:10.1038/369556a0
First paragraph & References | PDF (534K)
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| | Transport of cytoplasmic particles catalysed by an unconventional myosin in living Drosophila embryos 560
Valerie Mermall, James G. McNally & Kathryn G. Miller
doi:10.1038/369560a0
First paragraph & References | PDF (382K)
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| | Cloned Ca2+-dependent K+ channel modulated by a functionally associated protein kinase 563
Manuel Esguerra, Jing Wang, Christine D. Foster, John P. Adelman, R. Alan North & Irwin B. Levitan
doi:10.1038/369563a0
First paragraph & References | PDF (345K)
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| | Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo
565
Si Lok, Kenneth Kaushansky, Richard D. Holly, Joseph L. Kuijper, Catherine E. Lofton-Day, Pieter J. Oort, Francis J. Grant, Mark D. Heipel, Steve K. Burkhead, Janet M. Kramer, L. Anne Bell, Cindy A. Sprecher, Hal Blumberg, Rebecca Johnson, Donna Prunkard, Andrew F. T. Ching, Shannon L. Mathewes, Mason C. Bailey, John W. Forstrom, Michele M. Buddle, Sherri G. Osborn, Simon J. Evans, Paul O. Sheppard, Scott R. Presnell, Patrick J. O'Hara, Fredrick S. Hagen, Gerald J. Roth & Donald C. Foster
doi:10.1038/369565a0
First paragraph & References | PDF (469K)
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| | Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin 568
Kenneth Kaushansky, Si Lok, Richard D. Holly, Virginia C. Broudy, Nancy Lin, Mason C. Bailey, John W. Forstrom, Michele M. Buddle, Pieter J. Oort, Fredrick S. Hagen, Gerald J. Roth, Thalia Papayannopoulou & Donald C. Foster
doi:10.1038/369568a0
First paragraph & References | PDF (524K)
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| | c-Mpl ligand is a humoral regulator of megakaryocytopoiesis 571
Françoise Wendling, Eugene Maraskovsky, Najet Debili, Christina Florindo, Mark Teepe, Monique Titeux, Nassia Methia, Janine Breton-Gorius, David Cosman & William Vainchenker
doi:10.1038/369571a0
First paragraph & References | PDF (467K)
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| | The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA 574
Shou Waga, Gregory J. Hannon, David Beach & Bruce Stillman
doi:10.1038/369574a0
First paragraph & References | PDF (537K)
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| | RAD25 is a DMA helicase required for DNA repair and RNA polymerase II transcription 578
Sami N. Guzder, Patrick Sung, Véronique Bailly, Louise Prakash & Satya Prakash
doi:10.1038/369578a0
First paragraph & References | PDF (529K)
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| | Insights into autoregulation from the crystal structure of twitchin kinase 581
Shu-Hong Hu, Michael W. Parker, Jun Yi Lei, Matthew C. J. Wilce, Guy M. Benian & Bruce E. Kemp
doi:10.1038/369581a0
First paragraph & References | PDF (566K)
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| | Corrections | |
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| | The shape, expansion rate and distance of supernova 1993J from VLBI measurements 584
N. Bartel, M. F. Bietenholz, M. P. Rupen, J. E. Conway, A. J. Beasley, R. A. Sramek, J. D. Romney, M. A. Titus, D. A. Graham, V. I. Altunin, D. L. Jones, A. Rius, T. Venturi, G. Umana, R. L. Francis, M. L. McCall, M. G. Richer, C. C. Stevenson, K. W. Weiler, S. D. Van Dyk, N. Panagia, W. H. Cannon, J. Popelar & R. J. Davis
doi:10.1038/369584a0
PDF (84K)
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| | Water-based non-stick hydrophobic coatings 584
Donald L. Schmidt, Charles E. Coburn, Benjamin M. DeKoven, Gregg E. Potter, Gregory F. Meyers & Daniel A. Fischer
doi:10.1038/369584b0
PDF (84K)
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| | Product Review | |
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| | Molecules in motion 585
New tools for the chromatographer include an analytical workstation for the characterization and analysis of biomolecules by immunoassay and chromatography, and an assortment of columns, pumps, detectors and accessories.
doi:10.1038/369585a0
PDF (643K)
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| | Science and the Law | |
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| | A moral question for patent legislation 589
In considering the grounds on which to award patents for applications of germline gene therapy, the European Patent Office may have to decide on the basis of "morality". This should not be its job.
Richard Price & Simon Cohen
doi:10.1038/369589a0
PDF (148K)
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| | Guide to Authors | |
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| | 590
doi:10.1038/369590a0
PDF (147K)
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