Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Diverse sources of hippocampal unitary inhibitory postsynaptic potentials and the number of synaptic release sites

Nature volume 368, pages 823–828 (1994)Cite this article

A Correction to this article was published on 01 May 1997

Abstract

Dual intracellular recordings from microscopically identified neurons in the hippocampus reveal that the synaptic terminals of three morphologically distinct types of interneuron act through GABAA receptors. Each type of interneuron forms up to 12 synaptic contacts with a postsynaptic principal neuron, but each interneuron innervates a different domain of the surface of the postsynaptic neuron. Different kinetics of the postsynaptic effects, together with the strategic placement of synapses, indicate that these GABAergic interneurons serve distinct functions in the cortical network.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Kandel, E. R., Spencer, W. A. & Brinley, F. J. J. Neurophysiol. 24, 225–242 (1961).

    Article  CAS  Google Scholar 

  2. Andersen, P., Eccles, J. C. & Loyning, Y. Nature 198, 540–542 (1963).

    Article  ADS  CAS  Google Scholar 

  3. Miles, R. & Wong, R. K. S. J. Physiol., Lond. 338, 611–629 (1987).

    Article  Google Scholar 

  4. Lacaille, J.-C. & Schwartzkroin, P. A. J. Neurosci. 8, 1411–1424 (1988).

    Article  CAS  Google Scholar 

  5. Andersen, P., Eccles, J. C. & Loyning, Y. J. Neurophysiol. 27, 592–607 (1964).

    Article  CAS  Google Scholar 

  6. Andersen, P., Eccles, J. C. & Loyning, Y. J. Neurophysiol. 27, 608–619 (1964).

    Article  CAS  Google Scholar 

  7. Miles, R. & Wong, R. K. S. J. Physiol., Lond. 356, 97–113 (1984).

    Article  CAS  Google Scholar 

  8. Davies, C. H., Starkey, S. J., Pozza, M. F. & Collingridge, G. L. Nature 349, 609–611 (1991).

    Article  ADS  CAS  Google Scholar 

  9. Knowles, W. D. & Schwartzkroin, P. A. J. Neurosci. 1, 318–322 (1981).

    Article  CAS  Google Scholar 

  10. Miles, R. J. Physiol., Lond. 431, 659–676 (1990).

    Article  CAS  Google Scholar 

  11. Lacaille, J.-C., Mueller, A. L., Kunkel, D. D. & Schwartzkroin, P. A. J. Neurosci. 7, 1979–1993 (1987).

    Article  CAS  Google Scholar 

  12. Scharfman, H. E., Kunkel, D. D. & Schwartzkroin, P. A. Neuroscience 37, 693–707 (1990).

    Article  CAS  Google Scholar 

  13. Lorente de No, R. J. Psychol. Neural. 46, 113–177 (1934).

    Google Scholar 

  14. Somogyi, P., Nunzi, M. G., Gorio, A. & Smith, A. D. Brain Res. 259, 137–142 (1983).

    Article  CAS  Google Scholar 

  15. Kawaguchi, Y. & Hama, K. Expl Brain Res. 72, 494–502 (1988).

    Article  CAS  Google Scholar 

  16. Han, Z.-S., Buhl, E. H., Lörinczi, Z. & Somogyi, P. Eur. J. Neurosci. 5, 395–410 (1993).

    Article  CAS  Google Scholar 

  17. Halasy, K. & Somogyi, P. Eur. J. Neurosci. 5, 411–429 (1993).

    Article  CAS  Google Scholar 

  18. Gulyas, A. I., Miles, R., Hajos, N. & Freund, T. F. Eur. J. Neurosci. 5, 1729–1751 (1993).

    Article  CAS  Google Scholar 

  19. Staley, K. J. & Mody, I. J. Neurophysiol. 68, 197–212 (1992).

    Article  CAS  Google Scholar 

  20. Ribak, C. E., Vaughn, J. E. & Saito, K. Brain Res. 140, 315–332 (1978).

    Article  CAS  Google Scholar 

  21. Somogyi, P. et al. Brain Res. 332, 143–149 (1985).

    Article  CAS  Google Scholar 

  22. Nicoll, R. A., Malenka, R. C. & Kauer, J. A. Physiol. Rev. 70, 513–565 (1990).

    Article  CAS  Google Scholar 

  23. Edwards, F. A., Konnerth, A. & Sakmann, B. J. Physiol., Lond. 430, 213–249 (1990).

    Article  CAS  Google Scholar 

  24. Pearce, R. A. Neuron 10, 189–200 (1993).

    Article  CAS  Google Scholar 

  25. Vu, E. T. & Krasne, F. B. Science 255, 1710–1711 (1992).

    Article  ADS  CAS  Google Scholar 

  26. Alger, B. E. & Nicoll, R. A. Nature 281, 315–317 (1979).

    Article  ADS  CAS  Google Scholar 

  27. Misgeld, U., Deisz, R. A., Dodt, H. U. & Lux, H. D. Science 232, 1413–1415 (1986).

    Article  ADS  CAS  Google Scholar 

  28. Thomson, A. M. & Radpour, S. Eur. J. Neurosci. 3, 587–601 (1991).

    Article  CAS  Google Scholar 

  29. Miles, R. & Wong, R. K. S. J. Physiol., Lond. 373, 397–418 (1986).

    Article  CAS  Google Scholar 

  30. Gulyas, A. I. et al. Nature 366, 683–687 (1993).

    Article  ADS  CAS  Google Scholar 

  31. Muller, W. & Misgeld, U. J. Neurophysiol. 64, 46–56 (1990).

    Article  CAS  Google Scholar 

  32. Segal, M. Brain Res. 511, 163–164 (1990).

    Article  CAS  Google Scholar 

  33. Otis, T. S. & Mody, I. J. Neurophysiol. 67, 227–235 (1992).

    Article  CAS  Google Scholar 

  34. Stuart, G. J. & Sakmann, B. Nature 367, 69–72 (1994).

    Article  ADS  CAS  Google Scholar 

  35. Somogyi, P., Freund, T. F. & Cowey, A. Neuroscience 7, 2577–2607 (1982).

    Article  CAS  Google Scholar 

  36. Douglas, R. J. & Martin, K. A. C. Neural Comp. 2, 283–292 (1990).

    Article  Google Scholar 

  37. Lytton, W. W. & Sejnowski, T. J. J. Neurophysiol. 66, 1059–1079 (1991).

    Article  CAS  Google Scholar 

  38. Soltesz, I., Bourassa, J. & Deschenes, M. Neuroscience 57, 555–564 (1993).

    Article  CAS  Google Scholar 

  39. Szentagothai, J. & Arbib, M. A. Neurosci. Res. Prog. Bull. 12, 305–510 (1974).

    CAS  Google Scholar 

  40. Buhl, E. H., Han, Z.-S., Lörinczi, Z., Stezhka, V. V., Karnup, S. V. & Somogyi, P. J. Neurophysiol. (in the press).

  41. Hodgson, A. J., Penke, B., Erdei, A., Chubb, I. W. & Somogyi, P. J. Histochem. Cytochem. 33, 229–239 (1985).

    Article  CAS  Google Scholar 

  42. Froestl, W., Mickel, S. J., von Sprecher, G., Bittiger, H. & Olpe, H.-R. Pharmac. Commun. 2, 52–56 (1992).

    CAS  Google Scholar 

  43. Davies, C. H., Pozza, M. F. & Collingridge, G. L. Neuropharmacology 32, 1071–1073 (1993).

    Article  CAS  Google Scholar 

  44. Otis, T. S., Dekoninck, Y. & Mody, I. J. Physiol., Lond. 463, 391–407 (1993).

    Article  CAS  Google Scholar 

  45. Caddick, S. J. & Chad, J. E. J. Physiol., Lond. (in the press).

Download references

Author information

Authors and Affiliations

  1. Medical Research Council, Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford, 0X1 3TH, UK

    Eberhard H. Buhl, Katalin Halasy & Peter Somogyi

  2. Department of Zoology, Jozsef Attila University, Szeged, Hungary

    Katalin Halasy

Authors
  1. Eberhard H. Buhl
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Katalin Halasy
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Peter Somogyi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Buhl, E., Halasy, K. & Somogyi, P. Diverse sources of hippocampal unitary inhibitory postsynaptic potentials and the number of synaptic release sites. Nature 368, 823–828 (1994). https://doi.org/10.1038/368823a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/368823a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing