Nature 368, 633 - 635 (14 April 1994); doi:10.1038/368633a0

Brain regions associated with acquisition and retrieval of verbal episodic memory

T. Shallice^*, P. Fletcher^†‡, C. D. Frith^*†§, P. Grasby^†‡, R. S. J. Frackowiak^† & R. J. Dolan^†‡

^* Psychology Department, University College London, Gower Street, London WC1E 6TB, UK
^† MRC Cyclotron Unit, Hammersmith Hospital, DuCane Road, London W12 OHS, UK
^‡ Royal Free Hospital and School of Medicine, Roland Hill Street, London NWS 2QG, UK
National Hospital for Neurology and Neurosurgery and the Institute of Neurology, Queen Square, London WC1 3BG, UK
^§ To whom correspondence should be addressed

IT is widely held that conscious recall of past experiences involves a specific system—episodic memory¹. Patients with amnesia have gross impairments of episodic memory while other kinds of memory remain intact^2,3, suggesting that a separable brain system underlies episodic memory. We have used positron emission tomography (PET) to identify components of this system in normal volunteers. A dual-task interference paradigm⁴ was used to isolate brain areas associated with acquisition, and a cueing paradigm⁵ to isolate the areas concerned with retrieval from verbal episodic memory. Acquisition was associated with activity in the left pre-frontal cortex and the retrosplenial area, whereas retrieval was associated with activity in right prefrontal cortex and the precu-neus. Our results provide clear evidence that episodic memory involves a network of specific prefrontal and posterior structures^6,7 which can be fractionated into different component processes.

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