Nature 368, 208 - 214 (17 March 1994); doi:10.1038/368208a0

Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein

Konrad Basler^* & Gary Struhl^†

^* Zoologisches Institut, Universität Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland
^† Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York,

Drosophila limbs are subdivided into anterior and posterior compartments which derive from adjacent cell populations founded early in development. Evidence is now provided that posterior cells organize growth and cell patterning in both compartments by secreting hedgehog protein and that hedgehog protein acts indirectly by inducing neighbouring anterior cells to secrete decapentaplegic or wingless protein.

References

1.	Garcia-Bellido, A., Ripoll, P. & Morata, G. Nature New Biol. 245, 251−253 (1973). | PubMed | ChemPort |
2.	Crick, F. H. & Lawrence, P. A. Science 189, 340−347 (1975). | PubMed | ChemPort |
3.	Garcia-Bellido, A. Genetic Control of Wing Disc Development in Drosophila (Associated Scientific Publishers, New York, 1975).
4.	Morata, G. & Lawrence, P. A. Nature 255, 614−617 (1975). | PubMed | ISI | ChemPort |
5.	Lawrence, P. A. & Morata, G. Devl Biol. 50, 321−337 (1976). | ChemPort |
6.	DiNardo, S., Kuner, J. M., Theis, J. & O'Farrell, P. H. Cell 43, 59−69 (1985). | Article | PubMed | ISI | ChemPort |
7.	Kornberg, T., Siden, I., O'Farrell, P. H. & Simon, M. Cell 40, 45−53 (1985). | Article | PubMed | ISI | ChemPort |
8.	Hama, C., Ali, Z. & Kornberg, T. B. Genes Dev. 4, 1079−1093 (1990). | PubMed | ISI | ChemPort |
9.	Moazed, D. & O'Farrell, P. H. Development 116, 805−810 (1992). | PubMed | ISI | ChemPort |
10.	Vincent, J. P. & O'Farrell, P. H. Cell 68, 923−931 (1992). | Article | PubMed | ISI | ChemPort |
11.	Lawrence, P. A. & Struhl, G. EMBO J. 1, 827−833 (1982). | PubMed | ISI | ChemPort |
12.	Meinhardt, H. Devl Biol. 96, 375−385 (1983). | ChemPort |
13.	Nüsslein-Volhard, C. & Wieschaus, E. Nature 287, 795−801 (1980). | Article | PubMed | ChemPort |
14.	Spencer, F. A., Hoffmann, F. M. & Gelbart, W. M. Cell 28, 451−461 (1982). | Article | PubMed | ISI | ChemPort |
15.	Sharma, R. P. & Chopra, V. L. Devl Biol. 48, 461−465 (1976). | ChemPort |
16.	van-den-Heuvel, M., Nusse, R., Johnston, P. & Lawrence, P. A. Cell 59, 739−749 (1989). | PubMed | ChemPort |
17.	Panganiban, G. E., Rashka, K. E., Neitzel, M. D. & Hoffmann, F. M. Molec. cell. Biol. 10, 2669−2677 (1990). | PubMed | ChemPort |
18.	Panganiban, G. E., Reuter, R., Scott, M. P. & Hoffmann, F. M. Development 110, 1041−1050 (1990). | PubMed | ISI | ChemPort |
19.	Gonzalez, F., Swales, L., Bejsovec, A., Skaer, H. & Martinez-Arias, A. Mech. Dev. 35, 43−54 (1991). | Article | PubMed | ISI | ChemPort |
20.	Lee, J. J., von-Kessler, D. P., Parks, S. & Beachy, P. A. Cell 71, 33−50 (1992). | Article | PubMed | ISI | ChemPort |
21.	Taylor, A. M., Nakano, Y., Mohler, J. & Ingham, P. W. Mech. Dev. 43, 89−96 (1993).
22.	Baker, N. E. Devl Biol. 125, 96−108 (1988). | ChemPort |
23.	DiNardo, S., Sher, E., Heemskerk, J. J., Kassis, J. A. & O'Farrell, P. H. Nature 332, 604−609 (1988). | Article | PubMed | ISI | ChemPort |
24.	Martinez-Arias, A., Baker, N. E. & Ingham, P. W. Development 103, 157−170 (1988). | PubMed |
25.	Mohler, J. Genetics 120, 1061−1072 (1988). | PubMed | ISI | ChemPort |
26.	Immerglück, K., Lawrence, P. A. & Bienz, M. Cell 62, 261−268 (1990). | Article | PubMed | ISI |
27.	Posakony, L. G., Raftery, L. A. & Gelbart, W. M. Mech. Dev. 33, 69−82 (1990). | Article | PubMed | ChemPort |
28.	Ingham, P. W., Taylor, A. M. & Nakano, Y. Nature 353, 184−187 (1991). | Article | PubMed | ISI | ChemPort |
29.	Ferguson, E. L. & Anderson, K. V. Cell 71, 451−461 (1992). | Article | PubMed | ChemPort |
30.	Heberlein, U., Wolff, T. & Rubin, G. M. Cell 75, 913−926 (1993). | Article | PubMed | ISI | ChemPort |
31.	Ingham, P. W. Nature 366, 560−562 (1993). | Article | PubMed | ISI | ChemPort |
32.	Ingham, P. W. & Hidalgo, A. Development 117, 283−291 (1993). | PubMed | ISI | ChemPort |
33.	Ma, C., Zhou, Y., Beachy, P. A. & Moses, K. Cell 75, 927−938 (1993). | Article | PubMed | ISI | ChemPort |
34.	Struhl, G. & Basler, K. Cell 72, 527−540 (1993). | Article | PubMed | ISI | ChemPort |
35.	Cabrera, C. V., Alonso, M. C., Johnston, P., Phillips, R. G. & Lawrence, P. A. Cell 50, 659−663 (1987). | Article | PubMed | ChemPort |
36.	Padgett, R. W., St Johnston, R. D. & Gelbart, W. M. Nature 325, 81−84 (1987). | Article | PubMed | ISI | ChemPort |
37.	Rijsewijk, F. et al. Cell 50, 649−657 (1987). | Article | PubMed | ISI | ChemPort |
38.	Riddle, R. D., Johnson, R. L., Laufer, E. & Tabin, C. Cell 76, 1401−1416 (1993).
39.	Krauss, S., Concordet, J.-P. & Ingham, P. W. Cell 76, 1431−1444 (1993).
40.	Echelard, Y. et al. Cell 76, 1417−1430 (1993).
41.	Mohler, J. & Vani, K. Development 115, 957−971 (1992). | PubMed | ISI | ChemPort |
42.	Tabata, T., Eaton, S. & Kornberg, T. B. Genes Dev. 6, 2635−2645 (1992). | PubMed | ISI | ChemPort |
43.	Tashiro, S. et al. Gene 124, 183−189 (1993). | PubMed | ChemPort |
44.	Masucci, J. D., Miltenberger, R. J. & Hoffmann, F. M. Genes Dev. 4, 2011−2023 (1990). | PubMed | ChemPort |
45.	Blackman, R. K., Sanicola, M., Raftery, L. A., Gillevet, T. & Gelbart, W. M. Development 111, 657−666 (1991). | PubMed | ISI | ChemPort |
46.	Raftery, L. A., Sanicola, M., Blackman, R. K. & Gelbart, W. M. Development 113, 27−33 (1991). | PubMed | ChemPort |
47.	Couso, J. P., Bate, M. & Martinez-Arias, A. Science 259, 484−489 (1993). | PubMed | ISI | ChemPort |
48.	Broach, J. R. & Hicks, J. B. Cell 21, 501−508 (1980). | Article | PubMed | ISI | ChemPort |
49.	Theurkauf, W. E., Baum, H., Bo, J. & Wensink, P. C. Proc. natn. Acad. Sci. U.S.A. 83, 8477−8481 (1986). | ChemPort |
50.	Kassis, J. A., Noll, E., VanSickle, E. P., Odenwald, W. F. & Perrimon, N. Proc. natn. Acad. Sci. U.S.A. 89, 1919−1923 (1992). | ChemPort |
51.	Lawrence, P. A., Johnston, P., Macdonald, P. & Struhl, G. Nature 328, 440−442 (1987). | Article | PubMed | ISI | ChemPort |
52.	Bejsovec, A. & Martinez-Arias, A. Development 113, 471−485 (1991). | PubMed | ISI | ChemPort |
53.	Heemskerk, J., DiNardo, S., Kostriken, R. & O'Farrell, P. H. Nature 352, 404−410 (1991). | Article | PubMed | ISI | ChemPort |
54.	Peifer, M., Rauskolb, C., Williams, M., Riggleman, B. & Wieschaus, E. Development 11, 1029−1043 (1991).
55.	Williams, J. A., Paddock, S. W. & Carroll, S. B. Development 117, 571−584 (1993). | PubMed | ISI | ChemPort |
56.	Steiner, E. Wilhelm Roux Arch. EntwMech. Org. 180, 9−30 (1976).
57.	Campbell, G., Weaver, T. & Tomlinson, A. Cell 74, 1113−1123 (1993). | Article | PubMed | ISI | ChemPort |
58.	Blair, S. S. Development 119, 339−351 (1993). | PubMed | ISI | ChemPort |
59.	Diaz-Benjumea, F. J. & Cohen, S. M. Cell 75, 741−752 (1993). | Article | PubMed | ChemPort |
60.	Ready, D. F., Hanson, T. E. & Benzer, S. Devl Biol. 53, 217−240 (1976). | ChemPort |
61.	Anderson, R., Landry, M. & Muneoka, K. Development 117, 1421−1433 (1993). | PubMed | ChemPort |
62.	Niswander, L., Tickle, C., Vogel, A., Booth, I. & Martin, G. R. Cell 75, 579−587 (1993). | Article | PubMed | ISI | ChemPort |
63.	Placzek, M., Jessell, T. M. & Dodd, J. Development 117, 205−218 (1993). | PubMed | ChemPort |
64.	Vogel, A. & Tickle, C. Development 119, 199−206 (1993). | PubMed | ChemPort |
65.	Struhl, G. Devl Biol. 84, 372−385 (1981).
66.	Golic, K. Science 252, 958−961 (1991). | PubMed | ISI | ChemPort |
67.	Xu, T. & Rubin, G. M. Development 117, 1223−1237 (1993). | PubMed | ISI | ChemPort |
68.	Morata, G. & Ripoll, P. Dev. Biol. 42, 211−221 (1975). | Article | PubMed | ISI | ChemPort |
69.	Patel, N. H. et al. Cell 58, 955−968 (1989). | Article | PubMed | ISI | ChemPort |
70.	Eaton, S. & Kornberg, T. B. Genes Dev. 4, 1068−1077 (1990). | PubMed | ISI | ChemPort |
71.	Orenic, T. V., Slusarski, D. C., Kroll, K. L. & Holmgren, R. A. Genes Dev. 4, 1053−1067 (1990). | PubMed | ISI | ChemPort |
72.	Tabata, T. & Kornberg, T. Cell 76, 89−102 (1994). | Article | PubMed | ISI | ChemPort |