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Protein composition determines the anti-atherogenic properties of HDL in transgenic mice

Nature volume 365, pages 762–764 (1993)Cite this article

Abstract

HIGH-DENSITY lipoprotein (HDL) contains two major proteins, apolipoprotein A-I (apoA-I) and apolipoprotein A-II (apoA-II), comprising about 70% and 20% of the total HDL protein mass, respectively. HDL exists in human plasma in two main forms, one containing apoA-I with apoA-II (AI/AII-HDL) and another containing apoA-I without apoA-II (AI-HDL). A strong inverse relationship exists between total plasma HDL concentration and atherosclerosis, but the results of studies examining the relationship between AI-HDL and AI/AII-HDL and atherosclerosis have been conflicting1–9. To determine whether these two HDL populations have different effects on atherogenesis, human apoA-I (AI) and human apoA-I and apoA-II (AI/AII) transgenic mice were produced in an atherosclerosis-susceptible strain10–12. Following an atherogenic diet, despite similar total cholesterol and HDL cholesterol concentrations, the area of atherogenic lesions in the AI/AII mice was 15-fold greater than in the AI animals. These studies show that the protein composition of HDL significantly affects its role in atherogenesis and that AI-HDL is more anti-atherogenic than AI/AII-HDL.

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Author notes

  1. Edward M. Rubin: To whom correspondence should be addressed.

Authors and Affiliations

  1. Life Sciences Division, Lawrence Berkeley Laboratory, University of California, Berkeley, California, 94720, USA

    Joshua R. Schultz, Judy G. Verstuyft, Elaine L. Gong, Alex V. Nichols & Edward M. Rubin

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  1. Joshua R. Schultz
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  2. Judy G. Verstuyft
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  3. Elaine L. Gong
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  4. Alex V. Nichols
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  5. Edward M. Rubin
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Schultz, J., Verstuyft, J., Gong, E. et al. Protein composition determines the anti-atherogenic properties of HDL in transgenic mice. Nature 365, 762–764 (1993). https://doi.org/10.1038/365762a0

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