Nature Publishing Group, publisher of Nature, and other science journals and reference works
Nature
my account e-alerts subscribe register
   
Monday 26 June 2017
Journal Home
Current Issue
AOP
Archive
Download PDF
References
Export citation
Export references
Send to a friend
More articles like this

Letters to Nature
Nature 365, 548 - 550 (07 October 1993); doi:10.1038/365548a0

African and North American populations of Drosophila melanogaster are very different at the DNA level

David J. Begun & Charles F. Aquadro

Cornell University, Section of Genetics and Development, Biotechnology Building, Ithaca, New York 14853, USA

UNDERSTANDING genetic evolution within species requires an accurate description of variation within and between populations and the ability to distinguish between the potential causes of an observed distribution of variation. In the cosmopolitan species Drosophila melanogaster, previous studies suggested that gene flow within and between continents is extensive1 and that most of the nuclear gene variation is found within, rather than among, populations2,3. Here we present evidence that a population from Zimbabwe is more than twice as variable as those from the United States of America at the DNA sequence level, that most variants are not shared between the two geographic regions, and that there are nearly fixed differences between the Zimbabwe and USA samples in genomic regions experiencing low recombination rates. It appears that there is an unappreciated degree of population structure in D. melanogaster and that equilibrium models of molecular evolution are inappropriate for this species.

------------------

References

1. Singh, R. S. & Rhomberg, L. R. Genetics 115, 313−322 (1987).
2. Singh, R. S. & Rhomberg, L. R. Genetics 117, 255−271 (1987).
3. Kreitman, M. Nature 304, 412−417 (1983). | Article | PubMed | ISI | ChemPort |
4. Miyashita, N. T. Genetics 125, 407−419 (1990). | PubMed | ISI | ChemPort |
5. Miyashita, N. & Langley, C. H. Genetics 120, 199−212 (1988). | PubMed | ISI | ChemPort |
6. Martin-Campos, J. M., Cameron, J. M., Miyashita, N. & Aguadé, M. Genetics 130, 805−816 (1992). | PubMed | ChemPort |
7. Langley, C. H., MacDonald, J., Miyashita, N. & Aguadé, M. Proc. natn. Acad. Sci. U.S.A. 90, 1800−1803 (1993). | ChemPort |
8. Hudson, R. R., Boos, D. D. & Kaplan, N. L. Molec. Biol. Evol. 9, 138−151 (1992). | PubMed | ChemPort |
9. Tajima, F. Genetics 123, 585−595 (1989). | PubMed | ISI | ChemPort |
10. Eanes, W. F., Ajioka, J. W., Hey, J. & Wesley, C. Molec. Biol. Evol. 6, 384−397 (1989). | PubMed | ChemPort |
11. Eanes, W. F., Labate, J. & Ajioka, J. W. Molec. Biol. Evol. 6, 492−502 (1989). | PubMed | ChemPort |
12. Singh, R. S., Hickey, D. L. & David, J. Genetics 101, 235−256 (1982). | ISI | ChemPort |
13. David, J. R. & Capy, P. Trends Genet. 4, 106−111 (1988). | Article | PubMed | ChemPort |
14. Begun, D. J. & Aquadro, C. F. Nature 356, 519−520 (1992). | Article | PubMed | ISI | ChemPort |
15. Maynard Smith, J. & Haigh, J. Genet. Res. 23, 23−35 (1974). | PubMed |
16. Kaplan, N. L., Hudson, R. R. & Langley, C. H. Genetics 123, 887−899 (1989). | PubMed | ISI | ChemPort |
17. Charlesworth, B., Morgan, M. T. & Charlesworth, D. Genetics 134, 1289−1303 (1993). | PubMed | ISI | ChemPort |
18. Stephan, W. & Mitchell, S. J. Genetics 132, 1039−1045 (1992). | PubMed | ChemPort |
19. Hudson, R. Oxf. Surv. evol. Biol. 7, 1−44 (1990).
20. Kreitman, M. & Aguadé, M. Proc. natn. Acad. Sci. U.S.A. 83, 3562−3566 (1986). | ChemPort |
21. Hudson, R. R. Genetics 100, 711−719 (1982). | PubMed | ChemPort |
22. Nei, M. & Li, W.-H. Proc. natn. Acad. Sci. U.S.A. 76, 5269−5273 (1979). | ChemPort |
23. Hudson, R. R., Slatkin, M. & Maddison, W. P. Genetics 132, 583−589 (1992). | PubMed | ISI | ChemPort |
24. Hudson, R. R., Kreitman, M. & Aguadé, M. Genetics 116, 153−159 (1987). | PubMed | ISI | ChemPort |
25. Kreitman, M. & Hudson, R. R. Genetics 127, 565−582 (1991). | PubMed | ISI | ChemPort |
26. Lindsley, D. L. & Zimm, G. G. The Genome of Drosophila melanogaster (Academic, San Diego, 1992).



© 1993 Nature Publishing Group
Privacy Policy