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Letters to Nature
Nature 363, 350 - 353 (27 May 1993); doi:10.1038/363350a0

Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF

Ann M. Lohof, Nancy Y. Ip* & Mu-ming Poo

Department of Biological Sciences, Columbia University, New York, New York 10027, USA
*Regeneron Pharmaceuticals Inc., Tarrytown, New York 10591, USA
To whom correspondence should be addressed.

THE neurotrophins are a family of neurotrophic factors that promote survival and differentiation of various neuronal populations1,2. Although the long-term effects of neurotrophins on neuronal survival and differentiation have been intensively studied, nothing is known about their effects on synaptic function. Here we report that acute exposure to neurotrophin-3 (NT-3)3,4 or brain-derived neurotrophic factor (BDNF)5, but not nerve growth factor (NGF)6, rapidly potentiates the spontaneous and impulse-evoked synaptic activity of developing neuromuscular synapses in culture. The effect appears to be presynaptic in origin and to be mediated by the Trk family of receptor tyrosine kinases7. These results provide evidence for the regulation of the function of developing synapses by neurotrophins.

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References

1. Thoenen, H. Trends Neurosci. 14, 165−170 (1991). | Article | PubMed | ChemPort |
2. Lo, D. C. Curr. Opin. Neurobiol. 2, 336−340 (1992). | Article | PubMed | ChemPort |
3. Hohn, A., Leibrock, J., Bailey, K. & Barde, Y. A. Nature 344, 339−341 (1990). | Article | PubMed | ISI | ChemPort |
4. Maisonpierre, P. C. et al. Science 247, 1446−1451 (1990). | PubMed | ISI | ChemPort |
5. Leibrock, J. et al. Nature 341, 149−152 (1989). | Article | PubMed | ISI | ChemPort |
6. Levi-Montalcini, R. EMBO J. 6, 1145−1154 (1987). | PubMed | ChemPort |
7. Chao, M. V. Neuron 9, 583−593 (1992). | Article | PubMed | ISI | ChemPort |
8. Alderson, R. F., Alterman, A. L., Barde, Y.-A. & Lindsay, R. M. Neuron 5, 297−306 (1990). | Article | PubMed | ISI | ChemPort |
9. Hyman, C. et al. Nature 350, 230−232 (1991). | Article | PubMed | ChemPort |
10. Ip, N. Y. et al. Neuron 10, 137−149 (1993). | Article | PubMed | ISI | ChemPort |
11. Evers, J., Laser, M., Sun, Y., Xie, Z. & Poo, M-m. J. Neurosci. 9, 1523−1539 (1989). | PubMed | ISI | ChemPort |
12. Xie, Z.-P. & Poo, M-m. Proc. natn. Acad. Sci. U.S.A. 83, 7069−7073 (1986). | ChemPort |
13. Berg, M. M., Sternberg, D. W., Parada, L. F. & Chao, M. V. J. biol. Chem. 267, 13−16 (1992). | PubMed | ISI | ChemPort |
14. Tapley, P., Lamballe, F. & Barbacid, M. Oncogene 7, 371−381 (1992). | PubMed | ISI | ChemPort |
15. Nye, S. H. et al. Molec. Biol. Cell. 3, 677−686 (1992). | PubMed | ChemPort |
16. Knusel, B. & Hefti, F. J. Neurochem. 57, 955−962 (1991). | PubMed | ChemPort |
17. Squinto, S. P. et al. Cell 65, 885 (1991). | Article | PubMed | ISI | ChemPort |
18. Soppet, D. et al. Cell 65, 895 (1991). | Article | PubMed | ISI | ChemPort |
19. Lamballe, F., Klein, R. & Barbacid, M. Cell 66, 967−979 (1991). | Article | PubMed | ISI | ChemPort |
20. Cordon-Cardo, C. et al. Cell 66, 173−183 (1991). | Article | PubMed | ChemPort |
21. Bixby, J. L. & Spitzer, N. C. J. Physiol., Lond. 353, 143−155 (1984). | ChemPort |
22. Lo, Y.-J. & Poo, M-m. Science 254, 1019−1022 (1991). | PubMed | ISI | ChemPort |
23. Maisonpierre, P. C. et al. Neuron 5, 501−509 (1990). | Article | PubMed | ISI | ChemPort |
24. Wong, V., Arriaga, R., Ip, N. Y. & Lindsay, R. M. Eur. J. Neurosci. 5, 466−474 (1993). | PubMed | ChemPort |
25. DiStefano, P. S. et al. Neuron 8, 983−993 (1992). | Article | PubMed | ISI | ChemPort |
26. Oppenheim, R., Qin-Weim, Y., Prevette, D. & Yan, Q. Nature 360, 755−757 (1992). | Article | PubMed | ISI | ChemPort |
27. Yan, Q., Elliot, J. & Snider, W. D. Nature 360, 753−755 (1992). | Article | PubMed | ISI | ChemPort |
28. Sendtner, M., Holtmann, B., Kolbeck, R., Thoenen, H. & Barde, Y.-A. Nature 360, 757−759 (1992). | Article | PubMed | ISI | ChemPort |
29. Kidokoro, Y. & Saito, M. Proc. natn. Acad. Sci. U.S.A. 85, 1978−1982 (1988). | ChemPort |
30. Zafra, F., Hengerer, B., Leibrock, J., Thoenen, H. & Lindholm, D. EMBO J. 9, 3545−3550 (1990). | PubMed | ISI | ChemPort |
31. Isackson, P. J., Huntsman, M. M., Murray, K. D. & Gall, C. M. Neuron 6, 937−948 (1991). | Article | PubMed | ChemPort |
32. Lu, B., Yokoyama, M., Dreyfus, C. F. & Black, I. B. Proc. natn. Acad. Sci. U.S.A. 88, 6289−6292 (1991). | ChemPort |
33. Patterson, S. L., Grover, L. M., Schwartzkroin, P. A. & Bothwell, M. Neuron 9, 1081−1088 (1992). | Article | PubMed | ISI | ChemPort |
34. Tabti, N. & Poo, M-m. in Culturing Nerve Cells (eds Banker, G. & Goslin, K.) 137−153 (MIT, Cambridge, MA, 1991).
35. Hamill, O. P., Marty, A., Neher, E., Sakmann, B. & Sigworth, F. J. Pfluegers Arch. 391, 85−100 (1981). | Article | ChemPort |



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