Abstract
THE soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target mem-branes1–4. Here we report the cloning and sequencing of com-plementary DNAs encoding α-, β- and γ-SNAPs. Two of these proteins, α and γ, are found in a wide range of tissues, and act synergistically in intra-Golgi transport. The third, β, is a brain-specific isoform of α-SNAP. Thus, NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused, as described in the accompanying article4.
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Whiteheart, S., Griff, I., Brunner, M. et al. SNAP family of NSF attachment proteins includes a brain-specific isoform. Nature 362, 353–355 (1993). https://doi.org/10.1038/362353a0
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DOI: https://doi.org/10.1038/362353a0
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