Nature 362, 312 - 318 (25 March 1993); doi:10.1038/362312a0

Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system

Mark A. Marchionni^*, Andrew D. J. Goodearl^†, Maio Su Chen^*, Olivia Bermingham-McDonogh^*, Cassandra Kirk^*, Marvin Hendricks^*, Frank Danehy^*, Don Misumi^*, Judith Sudhalter^*, Kazumi Kobayashi^*‡, Diana Wroblewski^*, Catherine Lynch^*, Mark Baldassare^§, Ian Hiles^†, John B. Davis^†‡, J. Justin Hsuan^†, Nicholas F. Totty^†, Masayuki Otsu^†, Robert N. McBurney^*, Michael D. Waterfield^†, Paul Stroobant^† & David Gwynne^*

^*Cambridge NeuroScience Inc., One Kendall Square, Building 700, Cambridge, Massachusetts 02139, USA
^†Ludwig Institute for Cancer Research, Courtauld Building, 91 Riding House Street, London W1P 8BT, UK
^§Columbia University, Howard Hughes Medical Institute, 722 168th Street, New York, New York 10032, USA
^‡Present addresses: Biogen Inc., 14 Cambridge Center, Cambridge, Massachusetts 02142, USA (K.K.); Harvard Medical School, Neurobiology Department, 25 Shattuck Street, Building 52, Boston, Massachusetts 02115, USA (A.D.J.G.); The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA (J.B.D.).

Glial growth factors, proteins that are mitogenic for Schwann cells, and several ligands for the p85^erbB2 receptor, are products of the same gene. Alternative splicing of the messenger RNA generates an array of putative membrane-attached, intracellular and secreted signalling proteins, at least some of which are expressed in the developing spinal cord and brain. These factors are probably important in the development and regeneration of the nervous system.

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