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Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system

Nature volume 362, pages 312–318 (1993)Cite this article

Abstract

Glial growth factors, proteins that are mitogenic for Schwann cells, and several ligands for the p±85erbB2 receptor, are products of the same gene. Alternative splicing of the messenger RNA generates an array of putative membrane-attached, intracellular and secreted signalling proteins, at least some of which are expressed in the developing spinal cord and brain. These factors are probably important in the development and regeneration of the nervous system.

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Author information

Author notes

  1. Kazumi Kobayashi

    Present address: Biogen Inc., 14 Cambridge Center, Cambridge, Massachusetts, 02142, USA

  2. Andrew D. J. Goodearl

    Present address: Harvard Medical School, Neurobiology Department, 25 Shattuck Street, Building 52, Boston, Massachusetts, 02115, USA

  3. John B. Davis

    Present address: The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California, 92037, USA

Authors and Affiliations

  1. Cambridge NeuroScience Inc., One Kendall Square, Building 700, Cambridge, Massachusetts, 02139, USA

    Mark A. Marchionni, Maio Su Chen, Olivia Bermingham-McDonogh, Cassandra Kirk, Marvin Hendricks, Frank Danehy, Don Misumi, Judith Sudhalter, Kazumi Kobayashi, Diana Wroblewski, Catherine Lynch, Robert N. McBurney & David Gwynne

  2. Ludwig Institute for Cancer Research, Courtauld Building, 91 Riding House Street, London, W1P 8BT, UK

    Andrew D. J. Goodearl, Ian Hiles, John B. Davis, J. Justin Hsuan, Nicholas F. Totty, Masayuki Otsu, Michael D. Waterfield & Paul Stroobant

  3. Columbia University, Howard Hughes Medical Institute, 722 168th Street, New York, New York, 10032, USA

    Mark Baldassare

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Marchionni, M., Goodearl, A., Su Chen, M. et al. Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system. Nature 362, 312–318 (1993). https://doi.org/10.1038/362312a0

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