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Preferential representation of the fovea in the primary visual cortex

Abstract

THE retinal fovea, which corresponds to the central degree or so of vision, is spatially over-represented in the visual cortex. It is about 0.01% of retina area, but at least 8% of the striate cortex1–3. Does this simply reflect an equivalently uneven distribution of ganglion cells in the retina4–7, or is the cortical representation of the fovea preferentially expanded8–13? The answer hinges on the resolution of long-standing discrepancies between the retinal and cortical magnification factors. We approached the problem in a different way, using a retrograde transneuronal tracer from cortex to retina to relate directly the number of ganglion cells projecting to marked areas of striate cortex. We report here that ganglion cells near the fovea were allocated 3.3 to 5.9 times more cortical tissue than more peripheral ones, and conclude that the cortical representation of the most central retina is much greater than expected from the density of its ganglion cells.

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References

  1. Talbot, S. A. & Marshall, W. H. Am. J. Ophthalmol. 24, 1255–1264 (1941).

    Article  Google Scholar 

  2. Daniel, P. M. & Whitteridge, D. J. Physiol. 159, 203–221 (1961).

    Article  CAS  Google Scholar 

  3. Cowey, A. J. Neurophysiol. 27, 366–393 (1964).

    Article  CAS  Google Scholar 

  4. Drasdo, N. Nature 266, 554–556 (1977).

    Article  ADS  CAS  Google Scholar 

  5. Rovamo, J. & Virsu, V. Expl Brain Res. 37, 495–510 (1979).

    Article  CAS  Google Scholar 

  6. Wässle, H., Grünert, U., Röhrenbeck, J. & Boycott, B. B. Nature 341, 643–646 (1989).

    Article  ADS  Google Scholar 

  7. Wässle, H., Grünert, U., Röhrenbeck, J. & Boycott, B. B. Vision Res. 30, 1897–1911 (1990).

    Article  Google Scholar 

  8. Connolly, M. & Van Essen, D. C. J. comp. Neurol. 226, 544–564 (1984).

    Article  CAS  Google Scholar 

  9. Malpeli, J. G. & Baker, F. H. J. comp. Neurol. 161, 569–594 (1975).

    Article  CAS  Google Scholar 

  10. Myerson, J., Manis, P. B., Miezen, F. M. & Allman, J. M. Science 192, 855–857 (1977).

    Article  ADS  Google Scholar 

  11. Perry, V. H. & Cowey, A. Vision Res. 25, 1795–1810 (1985).

    Article  CAS  Google Scholar 

  12. Schein, S. J. J. comp. Neurol. 269, 479–505 (1988).

    Article  CAS  Google Scholar 

  13. Silveira, L. C. L., Picanco-Diniz, C. W., Sampaio, L. F. S. & Oswaldo-Cruz, E. Vision Res. 29, 1471–1483 (1989).

    Article  CAS  Google Scholar 

  14. LeVay, S. & Voigt, T. Expl Brain Res. 82, 77–81 (1990).

    Article  CAS  Google Scholar 

  15. Perry, V. H. & Cowey, A. Neuroscience 12, 1125–1137 (1984).

    Article  CAS  Google Scholar 

  16. Perry, V. H. & Cowey, A. Neuroscience 25, 225–236 (1988).

    Article  CAS  Google Scholar 

  17. Potts, A. M. et al. Invest. Ophthalmol. 11, 980–988 (1972).

    CAS  PubMed  Google Scholar 

  18. Rolls, E. T. & Cowey, A. Expl Brain Res. 10, 298–310 (1970).

    Article  CAS  Google Scholar 

  19. Perry, V. H. Neuroscience 6, 931–944 (1981).

    Article  CAS  Google Scholar 

  20. Dow, B. M., Snyder, A. Z., Vautin, R. G. & Bauer, R. Expl Brain Res. 44, 213–228 (1981).

    Article  CAS  Google Scholar 

  21. Hubel, D. H. & Wiesel, T. N. J. comp. Neurol. 158, 295–305 (1974).

    Article  CAS  Google Scholar 

  22. O'Kusky, J. & Collonier, M. J. comp. Neurol. 210, 278–290 (1982).

    Article  CAS  Google Scholar 

  23. Rockel, A. J., Hiorns, R. W. & Powell, T. P. S. Brain 103, 221–244 (1980).

    Article  CAS  Google Scholar 

  24. Powell, T. P. S. & Hendrickson, A. E. Brian Res. 216, 409–413 (1981).

    Article  CAS  Google Scholar 

  25. Levi, D. M., Klein, S. A. & Aitsebaomo, A. P. Vision Res. 27, 581–597 (1985).

    Article  Google Scholar 

  26. Fendick, M. & Westheimer, G. Vision Res. 23, 145–150 (1983).

    Article  CAS  Google Scholar 

  27. Blatherwick, P. & Hallet, P. E. in Seeing Contour and Colour (eds Kulikowski, J. J., Dickinson, C. M. & Murray, I. J.) 274–281 (Pergamon, Oxford 1989).

    Google Scholar 

  28. Strasburger, H., Harvey, L. O. Jr & Rentschler, I. Percept. Psychophys. 49, 495–508 (1991).

    Article  CAS  Google Scholar 

  29. Levi, D. M., Klein, S. A. & Aitsebaomo, A. P. Vision Res. 24, 789–900 (1984).

    Article  CAS  Google Scholar 

  30. Jenkins, W. M., Merzenich, M. M., Ochs, M. T., Allard, T. & Guic-Robles, E. J. Neurophysiol. 63, 82–104 (1990).

    Article  CAS  Google Scholar 

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Azzopardi, P., Cowey, A. Preferential representation of the fovea in the primary visual cortex. Nature 361, 719–721 (1993). https://doi.org/10.1038/361719a0

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