Access
To read this story in full you will need to login or make a payment (see right).
Review
Nature 360, 434-439 (3 December 1992) | doi:10.1038/360434a0; Accepted 27 October 1992
Molecular analysis of the association of HLA-B53 and resistance to severe malaria
Adrian V. S. Hill*, John Elvin*, Anthony C. Willis†, Michael Aidoo‡, Catherine E. M. Allsopp*, Frances M. Gotch*, X. Ming Gao*, Masafumi Takiguchis§, Brian M. Greenwood‡, Alain R. M. Townsend*, Andrew J. McMichael* & Hilton C. Whittle‡
Abstract
The protective association between the human leukocyte antigen HLA-B53 and severe malaria was investigated by sequencing of peptides eluted from this molecule followed by screening of candidate epitopes from pre-erythrocytic-stage antigens of Plasmodium falciparum in biochemical and cellular assays. Among malaria-immune Africans, HLA-B53-restricted cytotoxic T lymphocytes recognized a conserved nonamer peptide from liver-stage-specific antigen-1 (LSA-1), but no HLA-B53-restricted epitopes were identified in other antigens. These findings indicate a possible molecular basis for this HLA-disease association and support the candidacy of liver-stage-specific antigen-1 as a malaria vaccine component.
To read this story in full you will need to login or make a payment (see right).
