| | Opinion |  |
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| | New drug law to speed scientific review 563
By charging drug companies 'user fees' that will be spent hiring new staff, the US Food and Drug Administration will reduce the time it takes to review new pharmaceuticals from an average of two years to one.
doi:10.1038/359563a0
PDF (118K)
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| | Biodiversity supported 563
Funding for a new programme, with only $1.5 million for grants, is hardly enough to scratch the surface.
doi:10.1038/359563b0
PDF (234K)
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| | Copernican Columbus? 564
Columbus, for all the criticism of the past few weeks, deserves his place in history.
doi:10.1038/359564a0
PDF (133K)
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| | News | |
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| | If biological diversity has a price, who sets it and who should benefit? 565
Diane Gershon
doi:10.1038/359565a0
PDF (133K)
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| | New rules loom for US science funding as Congress passes a lean 1993 budget 566
Christopher Anderson, Jeffrey Mervis & Traci Watson
doi:10.1038/359566a0
PDF (267K)
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| | Human Frontiers looks for leader in Europe; US wavers 567
David Swinbanks & Alison Abbott
doi:10.1038/359567a0
PDF (148K)
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| | User fees to hasten FDA review 567
Diane Gershon
doi:10.1038/359567b0
PDF (148K)
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| | Sandoz-funded research from Rhine spill suggests blockages are worse than toxins 568
Oliver Klaffke & Alison Abbot
doi:10.1038/359568a0
PDF (133K)
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| | Science fares well in tight 1993 French budget 568
Declan Butler
doi:10.1038/359568b0
PDF (133K)
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| | Britain wrestles with EC rule on modified organisms 569
Ian Mundell
doi:10.1038/359569a0
PDF (145K)
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| | Overregulation could damage US biotechnology, says report 569
Sally Lehrman
doi:10.1038/359569b0
PDF (145K)
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| | Brian Henderson named president of Salk Institute 569
Traci Watson
doi:10.1038/359569c0
PDF (145K)
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| | Nobel Prize given for work on protein phosphorylation 570
Christopher Anderson
doi:10.1038/359570a0
PDF (144K)
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| | NOAA appoints ombudsman to repair frayed ties with universities 570
Christopher Anderson
doi:10.1038/359570b0
PDF (144K)
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| | Perkin-Elmer to buy Applied Biosystems to broaden markets 570
Diane Gershon
doi:10.1038/359570c0
PDF (144K)
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| | Correspondence | |
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| | Plight of Bosnia and Croatia 571
Velimir Pravdi
doi:10.1038/359571a0
PDF (149K)
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| | Plight of Bosnia and Croatia 571
Sead Dori
doi:10.1038/359571b0
PDF (149K)
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| | Plight of Bosnia and Croatia 571
Ivan Dikic
doi:10.1038/359571c0
PDF (149K)
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| | Commentary |  |
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| | HIV: to vaccinate or not to vaccinate? 572
"Improbability of effective vaccination against human immunodeficiency virus...",declares the title of a newpaper by Dr Albert Sabin. But three immunologists see flaws in his argument.
Gordon Ada, Bob Blanden & Arno Mullbacher
doi:10.1038/359572a0
References | PDF (141K)
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| | SCIENCE IN JAPAN | |
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| | Reforming Japan's science for the next century 573
doi:10.1038/359573a0
PDF (2,298K)
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| | News and Views |  |
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| | Messing around with gravity 583
Attempts to dispense with the need for galactic dark matter by altering the inverse square law of gravitational attraction have attracted a small but persistent advocacy.
David Lindley
doi:10.1038/359583a0
PDF (144K)
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| | Collision complexes clocked in real time 584
Roger Grice
doi:10.1038/359584a0
References | PDF (287K)
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| | Stellar opacities in a flash 585
D. B. Guenther
doi:10.1038/359585a0
References | PDF (128K)
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| | No muscles, but what a brain 586
Patrick Lemaire
doi:10.1038/359586a0
References | PDF (412K)
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| | Life and the rock cycle 587
Ján Veizer
doi:10.1038/359587a0
References | PDF (394K)
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| | The ACE of hearts 588
Theodore W. Kurtz
doi:10.1038/359588a0
References | PDF (312K)
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| | Chemical communications 589
Tim Lincoln
doi:10.1038/359589a0
PDF (186K)
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| | Beaming down 590
doi:10.1038/359590a0
PDF (148K)
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| | Future attractions 590
doi:10.1038/359590b0
PDF (148K)
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| | Solar sterilization 590
doi:10.1038/359590c0
PDF (148K)
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| | Drawing upon the mind's eye 590
Jennifer M. Gurd & John C. Marshall
doi:10.1038/359590d0
References | PDF (264K)
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| | Nanostructures come of age 591
Robert W. Cahn
doi:10.1038/359591a0
References | PDF (257K)
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| | High vacuum 592
David Jones
doi:10.1038/359592a0
PDF (141K)
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| | Scientific Correspondence | |
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| | Some like it hot . . . 593
Anindya Sinha & K. Chandrashekara
doi:10.1038/359593a0
References | PDF (213K)
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| | . . . and some even hotter 593
Pierre Chevaldonné, Daniel Desbruyéres & James J. Childress
doi:10.1038/359593b0
References | PDF (331K)
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| | Neural networks and olive oil 594
Royston Goodacre, Douglas B. Kell & Giorgio Bianchi
doi:10.1038/359594a0
References | PDF (136K)
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| | Book Reviews | |
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| | Newtonian rigour 595
William R. Shea reviews The Investigation of Difficult Things: Essays on Newton and the History of the Exact Sciences
Edited by
Peter M. Harman & Alan E. Shapiro
doi:10.1038/359595a0
PDF (306K)
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| | Large cast, but no plot 596
Gregory A. Petsko reviews Macromolecular Structures 1991/1992
Edited by
Wayne A. Hendrickson, Kurt Wüthrich & A. M. Lesk
doi:10.1038/359596a0
PDF (292K)
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| | Life and the single gene 597
Niles Lehman reviews Steps Towards Life: A Perspective on Evolution
By
Manfred Eigen
doi:10.1038/359597a0
PDF (287K)
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| | Flower power 598
G. R. Moore reviews Pigment of the Imagination: A History of Phytochrome Research
By
Linda C. Sage
doi:10.1038/359598a0
PDF (146K)
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| | Review Articles | |
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| | Creative blocks: cell-cycle checkpoints and feedback controls 599
Andrew W. Murray
doi:10.1038/359599a0
Abstract & References | PDF (946K)
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| | Box 1 A cell cycle refresher 601
doi:10.1038/359601a0
PDF (327K)
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| | Articles |  |
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| | Carbon isotope evidence for the stepwise oxidation of the Proterozoic environment 605
David J. Des Marais, Harald Strauss, Roger E. Summons & J. M. Hayes
doi:10.1038/359605a0
Abstract & References | PDF (770K)
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| | A truncated activin receptor inhibits mesoderm induction and formation
of axial structures in Xenopus embryos 609
Ali Hemmati-Brivanlou & Douglas A. Melton
doi:10.1038/359609a0
Abstract & References | PDF (767K)
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| | Letters | |
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| | Pulsed high-energy  -rays from the radio pulsar PSRI706−44 615
D. J. Thompson, Z. Arzoumanian, D. L. Bertsch, K. T. S. Brazier, N. D'Amico, C. E. Fichtel, J. M. Fierro, R. C. Hartman, S. D. Hunter, S. Johnston, G. Kanbach, V. M. Kaspi, D. A. Kniffen, Y. C. Lin, A. G. Lyne, R. N. Manchester, J. R. Mattox, H. A. Mayer-Hasselwander, P. F. Michelson, C. v. Montigny, H. I. Nel, D. Nice, P. L. Nolan, K. Pinkau, H. Rothermel, E. J. Schneid, M. Sommer, P. Sreekumar & J. H. Taylor
doi:10.1038/359615a0
First paragraph & References | PDF (224K)
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| | Pulsar glitches as probes of neutron star interiors 616
Bennett Link, Richard I. Epstein & Kenneth A. Van Riper
doi:10.1038/359616a0
First paragraph & References | PDF (389K)
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| | Gravitational wakes in Saturn's rings 619
H. Salo
doi:10.1038/359619a0
First paragraph & References | PDF (368K)
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| | Ferroelectric liquid crystals from achiral molecules 621
F. Tournilhac, L. M. Blinov, J. Simon & S. V. Yablonsky
doi:10.1038/359621a0
First paragraph & References | PDF (495K)
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| | Lead isotope evidence for young trace element enrichment in the oceanic upper mantle 623
Alex N. Halliday, Gareth R. Davies, Der-Chuen Lee, Simone Tommasini, Cassi R. Paslick, J. Godfrey Fitton & Dodie E. James
doi:10.1038/359623a0
First paragraph & References | PDF (940K)
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| | A sharp and flat section of the core−mantle boundary 627
John E. Vidale & Harley M. Benz
doi:10.1038/359627a0
First paragraph & References | PDF (385K)
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| | Blade-shaped conodont elements functioned as cutting teeth 629
Mark A. Purnell & Peter H. von Bitter
doi:10.1038/359629a0
First paragraph & References | PDF (404K)
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| | Cuckoldry through stored sperm in the sequentially polyandrous spotted sandpiper 631
Lewis W. Oring, Robert C. Fleischer, J. Michael Reed & Katherine E. Marsden
doi:10.1038/359631a0
First paragraph & References | PDF (469K)
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| | High outcrossing rates maintain male and hermaphrodite individuals in populations of the flowering plant Datisca glomerata
633
Peter Fritsch & Loren H. Rieseberg
doi:10.1038/359633a0
First paragraph & References | PDF (584K)
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| | Dissociation between mental imagery and object recognition in a brain-damaged patient 636
Marlene Behrmann, Gordon Winocur & Morris Moscovitch
doi:10.1038/359636a0
First paragraph & References | PDF (227K)
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| | Hippocampus-dependent learning facilitated by a monoclonal antibody or D-cycloserine 638
Lucien T. Thompson, Joseph R. Moskal & John F. Disterhoft
doi:10.1038/359638a0
First paragraph & References | PDF (589K)
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| | Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction 641
François Cambien, Odette Poirier, Laure Lecerf, Alun Evans, Jean-Pierre Cambou, Dominique Arveiler, Gerald Luc, Jean-Marie Bard, Lucienne Bara, Sylvain Ricard, Laurence Tiret, Philippe Amouyel, François Alhenc-Gelas & Florent Soubrier
doi:10.1038/359641a0
First paragraph & References | PDF (579K)
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| | Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase 644
Stephen M. Keyse & Elizabeth A. Emslie
doi:10.1038/359644a0
First paragraph & References | PDF (988K)
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| | A functional barrier to movement of lipids in polarized neurons 647
Toshihide Kobayashi, Brian Storrie, Kai Simons & Carlos G. Dotti
doi:10.1038/359647a0
First paragraph & References | PDF (626K)
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| | Identification of an amino acid−base contact in the GCN4−DNA complex by bromouracil-mediated photocrosslinking 650
Erich E. Blatter, Yon W. Ebright & Richard H. Ebright
doi:10.1038/359650a0
First paragraph & References | PDF (460K)
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| | Short alanine-based peptides may form 310-helices and not  -helices in aqueous solution 653
Siobhan M. Miick, Gary V. Martinez, Wayne R. Fiori, A. Paul Todd & Glenn L. Millhauser
doi:10.1038/359653a0
First paragraph & References | PDF (399K)
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| | Erratum | |
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| | Direct measurement of the optical depth in a spiral galaxy 655
Raymond E. White III & William C. Keel
doi:10.1038/359655a0
PDF (122K)
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| | Guide to Authors | |
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| | 656
doi:10.1038/359656a0
PDF (150K)
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