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Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein

Nature volume 357, pages 82–85 (1992)Cite this article

Abstract

THE cellular phosphoprotein p53 inhibits progression through the mammalian cell cycle1,2. Both p53 alleles are frequently mutated in human tumours3,4, indicating that p53 is a tumour suppressor. Recent studies have suggested that p53 functions as a transcrip-tional activator5–8, but the significance of this activity in cell-cycle control has not been established. The adenovirus 2 (Ad2) early IB (E1B) 55K protein binds to p53 in transformed cells9 and contributes to oncogenic transformation by Ad2 (refs 10-12). Here we report that mutants of E1B 55K and wild-type Adl2 E1B 54K proteins show a strong correlation between their ability to inhibit p53-mediated transcriptional activation and their ability to cooperate with adenovirus El A protein in the transformation of primary cells. These results indicate that p53 probably inhibits cell cycling by functioning as a transcription factor.

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Authors and Affiliations

  1. Department of Microbiology and Molecular Genetics and the Molecular Biology Institute, University of California, Los Angeles, California, 90024-1570, USA

    P. Renee Yew & Arnold J. Berk

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  1. P. Renee Yew
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  2. Arnold J. Berk
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Yew, P., Berk, A. Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein. Nature 357, 82–85 (1992). https://doi.org/10.1038/357082a0

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