Abstract
The gene ced-9 of the nematode Caenorhabditis elegansacts to protect cells from programmed cell death. A mutation that abnormally activatesced-9 prevents the cell deaths that occur during normal C. elegans development. Conversely, mutations that inactivate ced-9 cause cells that normally live to undergo programmed cell death; these mutations result in embryonic lethality, indicating that ced-9 function is essential for development. The ced-9 gene functions by negatively regulating the activities of other genes that are required for the process of programmed cell death.
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References
Glücksmann, A. A. Biol. Rev. Cambridge Phil. Soc. 26, 59–86 (1950).
Saunders, J. Science 154, 604–612 (1966).
Ellis, R. E., Yuan, J. & Horvitz, H. R. A. Rev. Cell Biol. 7, 663–698 (1991).
Lockshin, R. A. J. Insect. Physiol. 15, 1505–1516 (1969).
Cohen, J. J. & Duke, R. C. J. Immun. 132, 38–42 (1984).
Martin, D. P. et al. J. Cell Biol. 106, 829–844 (1988).
Schwartz, L. M., Kosz, L. & Kay, B. K. Proc. natn. Acad. Sci. U.S.A. 87, 6594–6598 (1990).
Sulston, J. E. & Horvitz, H. R. Devl Biol. 56, 110–156 (1977).
Sulston, J. E., Schierenberg, E., White, J. G. & Thomson, J. N. Devl Biol. 100, 64–119 (1983).
Robertson, A. & Thomson, N. J. Embryol. exp. Morph. 67, 89–100 (1982).
Hedgecock, E. M., Sulston, J. E. & Thomson, J. N. Science 220, 1277–1279 (1983).
Ellis, H. M. & Horvitz, H. R. Cell 44, 817–829 (1986).
Ellis, R. E., Jacobson, D. M. & Horvitz, H. R. Genetics 129, 79–94 (1991).
Yuan, J. Y. & Horvitz, H. R. Devl Biol. 138, 33–41 (1990).
Ellis, R. E. & Horvitz, H. R. Development 112, 591–603 (1991).
Albertson, D. G. & Thomson, J. N. Phil. Trans. R. Soc. B275, 299–325 (1976).
Brenner, S. Genetics 77, 71–94 (1974).
Meneely, P. M. & Herman, R. K. Genetics 92, 99–115 (1979).
Greenwald, I. S. & Horvitz, H. R. Genetics 96, 147–164 (1980).
Trent, C., Tsung, N. & Horvitz, H. R. Genetics 104, 619–647 (1983).
White, J. G., Southgate, E., Thomson, J. N. & Brenner, S. Phil. Trans. R. Soc. B311, 1–340 (1986).
Desai, C., Garriga, G., McIntire, S. L. & Horvitz, H. R. Nature 336, 638–646 (1988).
Desai, C. & Horvitz, H. R. Genetics 121, 703–721 (1989).
Kimble, J. & Hirsh, D. Devl Biol. 70, 396–417 (1979).
Sulston, J. E., Albertson, D. G. & Thomson, J. N. Devl Biol. 78, 542–576 (1980).
Chalfie, M. & White, J. in The Nematode Caenorhabditis elegans (eds Wood, W. B. et al.) 337–391 (Cold Spring Harbor Laboratory Press, New York, 1988).
Barde, Y. A. Neuron 2, 1525–1534 (1989).
Vaux, D. L., Cory, S. & Adams, J. M. Nature 335, 440–442 (1988).
Henderson, S. et al. Cell 65, 1107–1115 (1991).
Clem, R. J., Fechheimer, M. & Miller, L. K. Science 254, 1388–1390 (1991).
Nun̄ez, G. et al. J. Immun. 144, 3602–3610 (1990).
Sentman, C. L., Shutter, J. R., Hockenbery, D., Kanagawa, O. & Korsmeyer, S. J. Cell 67, 879–888 (1991).
Strasser, A., Harris, A. W. & Cory, S. Cell 67, 889–899 (1991).
Duke, R. C. & Cohen, J. J. Lymphokine Res. 5, 289–299 (1986).
Hockenbery, D. M., Zutter, M., Hickey, W., Nahm, M. & Korsmeyer, S. J. Proc. natn. Acad. Sci. U.S.A. 88, 6961–6965 (1991).
Choi, D. W. Neuron 1, 623–634 (1988).
Rosenbluth, R. E. & Baillie, D. L. Genetics 99, 415–428 (1981).
Avery, L. & Horvitz, H. R. Cell 51, 1071–1078 (1987).
Miller, L. M., Plenefisch, J. D., Casson, L. P. & Meyer, B. J. Cell 55, 167–183 (1988).
Cassada, R., Isnenghi, E., Culotti, M. & von Ehrenstein, G. Devl Biol. 84, 193–205 (1981).
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Hengartner, M., Ellis, R. & Horvitz, R. Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature 356, 494–499 (1992). https://doi.org/10.1038/356494a0
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DOI: https://doi.org/10.1038/356494a0
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