Nature Publishing Group, publisher of Nature, and other science journals and reference works
Nature
my account e-alerts subscribe register
   
Wednesday 23 August 2017
Journal Home
Current Issue
AOP
Archive
Download PDF
References
Export citation
Export references
Send to a friend
More articles like this

Letters to Nature
Nature 354, 233 - 235 (21 November 1991); doi:10.1038/354233a0

CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1

Yvonne Rosenstein*, John K. Park*, William C. Hahn*, Fred S. Rosen§, Barbara E. Bierer* & Steven J. Burakoff*

*Division of Pediatric Oncology, Dana-Farber Cancer Institute,§The Center for Blood Research, Hematology-Oncology Division, Brigham and Women's Hospital, and the Departments of Pathology, Pediatrics, and Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA

THE protein CD43 (also known as sialophorin, leukosialin, large sialoglycoprotein or gp115) is expressed on the surface of T lymphocytes, monocytes, neutrophils, platelets and some B lymphocytes1–6. Expression of CD43 is deficient and/or defective in the X-chromosome-linked immunodeficiency disorder Wiscott-Aldrich syndrome7, suggesting that CD43 might have a role in T-cell activation. We have shown that expression of human CD43 in an HLA-DR-specific murine T-cell hybridoma enhances the antigen-specific response to stimulation by the human lympho-blastoid cell line Daudi, and that Daudi cells bind specifically to purified immobilized CD43 (ref. 8). These data indicate that the specific interaction of CD43 with a ligand on the surface of Daudi cells might contribute to T-cell activation. Here we report evidence that intercellular adhesion molecule-1 (ICAM-1, or CD54), is a ligand for CD43.

------------------

References

1. Gamberg, C. G., Haÿry, P. & Anderson, L. C. J. Cell Biol. 68, 642−653 (1976). | Article | PubMed | ISI | ChemPort |
2. Brown, W. R. A., Barclay, N., Sunderland, C. A. & Williams, A. Nature 289, 456−460 (1981). | Article | PubMed | ChemPort |
3. Carlsson, S. R. & Fukuda, M. J. biol. Chem. 261, 12779−12786 (1986). | PubMed | ChemPort |
4. Remold-O'Donnell, E., Zimmerman, C., Kenney, D. & Rosen, F. Blood 70, 104−109 (1987). | PubMed |
5. Borche, L., Lozano, F., Vilella, R. & Vives, J. Eur. J. Immun. 17, 1523−1526 (1987). | ChemPort |
6. Wicken, M., Bjozck, P., Axelsson, B. & Perlmann, P. Scand. J. Immun. 28, 457−464 (1988). | ChemPort |
7. Parkman, R., Remold-O'Donnell, E., Kenney, D., Perrine, S. & Rosen, F. Lancet ii, 1387−1389 (1981).
8. Park, J. K. et al. Nature 350, 706−709 (1991). | Article | PubMed | ChemPort |
9. Clark, E. A., Ledbetter, J. A., Holly, R. C., Dinndorf, P. A. & Shu, G. Hum. Immun. 16, 100−113 (1986). | PubMed | ChemPort |
10. Rothlein, R., Dustin, M. L., Marlin, S. D. & Springer, T. A. J. Immun. 137, 1270−1274 (1986). | PubMed | ChemPort |
11. Dorken, B., Moller, P., Pezzutto, A., Schwartz-Albiez, R. & Moldenhauer, G. in Leucocyte Typing IV (ed. Knapp, W.) 3−32 (Oxford University Press, 1989).
12. Stoll, M., Dalchau, R. & Schmidt, R. in Leucocyte Typing IV (ed. Knapp, W.) 605−608 (Oxford University Press, 1989).
13. Axelsson, B., Youseffi-Etemad, R., Hammarstrom, S. & Perlmann, P. J. Immun. 141, 2912−2917 (1988). | PubMed | ChemPort |
14. Sanchez-Madrid, F. et al. Proc. natn. Acad. Sci. U.S.A. 79, 7489−7493 (1982). | ChemPort |
15. Bierer, B. E., Peterson, A., Barbosa, J., Seed, B. & Burakoff, S. J. Proc. natn. Acad. Sci. U.S.A. 85, 1154−1198 (1988).
16. Marlin, S. O. et al. Nature 344, 70−72 (1990). | PubMed | ChemPort |
17. Hahn, W. C., Rosenstein, Y., Burakoff, S. J. & Bierer, B. E. J. Immun. 147, 14−21 (1991). | PubMed | ChemPort |
18. Johnston, C., Dustin, M., Hibbs, M. & Springer, T. A. J. Immun. 145, 1181−1187 (1990). | PubMed |
19. Sanchez-Madrid, F., Davignon, D., Martz, E. & Springer, T. A. Cell Immun. 73, 1−11 (1982). | ChemPort |
20. Springer, T. A., Dustin, M. L., Kishimoto, T. K. & Martin, S. D. A. Rev. Immun. 223−252 (1987). | ChemPort |
21. Diamond, M. S. et al. J. Cell Biol. 111, 3129−3139 (1990). | Article | PubMed | ISI | ChemPort |
22. Larson, R. S. & Springer, T. A. Immunol. Rev. 114, 181−217 (1990). | PubMed | ISI | ChemPort |
23. Staunton, D. E., Dustin, M. L., Erikson, H. P. & Springer, T. A. Cell 61, 242−254 (1990).
24. Diamond, M. S., Staunton, D. E., Marlin, S. D. & Springer, T. A. Cell 65, 961−971 (1991). | Article | PubMed | ISI | ChemPort |
25. Silvermann, L. B. et al. J. Immun. 142, 4194−4200 (1989). | PubMed |
26. Mentzer, S. et al. J. exp. Med. 165, 1383−1392 (1987). | Article | PubMed | ChemPort |
27. Beyers, A. D., Barclay, A. N., Law, D. A., He, Q. & Williams, A. F. Immunol. Rev. 111, 59−77 (1989). | PubMed | ChemPort |
28. Nong, Y. H., Remold-O'Donnell, E., LeBien, T. W. & Remold, H. G. J. exp. Med. 170, 259−267 (1989). | Article | PubMed | ChemPort |
29. Cyster, J. G., Shotton, D. M. & Williams, A. EMBO J. 10, 893−902 (1991). | PubMed | ISI | ChemPort |
30. Ardman, B., Sikorski, M., Settles, M. & Staunton, D. E. J. exp. Med. 172, 1151−1158 (1990). | Article | PubMed | ChemPort |
31. Gorga, J. C., Knudsen, P. J., Foran, J. A., Strominger, J. L. & Burakoff, S. J. Cell. Immun. 103, 160−173 (1986). | Article | ChemPort |
32. Goldstein, S. A. & Mescher, M. J. Immun. 137, 3383−3392 (1986). | PubMed | ChemPort |
33. Takai, Y., Reed, M., Burakoff, S. J. & Herrmann, S. Proc. natn. Acad. Sci. U.S.A. 84, 6864−6868 (1987). | ChemPort |



© 1991 Nature Publishing Group
Privacy Policy