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Nature 351, 542-547 (13 June 1991) | doi:10.1038/351542a0; Accepted 9 May 1991

Genetic analysis of autoimmune type 1 diabetes mellitus in mice

John A. Todd, Timothy J. Aitman, Richard J. Cornall, Soumitra Ghosh, Jennifer R. S. Hall, Catherine M. Hearne, Andrew M. Knight*, Jennifer M. Love, Marcia A. McAleer, Jan-Bas Prins, Nanda Rodrigues, Mark Lathrop†, Alison Pressey†, Nicole H. DeLarato‡, Laurence B. Peterson§ & Linda S. Wicker‡

  1. Nuffield Department of Surgery, John Radcliffe Hospital, Headington, Oxford 0X3 9DU, UK
  2. *Transplantation Biology, Clinical Research Centre, Watford Road, Harrow, Middlesex HA1 3UJ, UK
  3. †CEPH, 27 rue Juliette Dodu, Paris 75010, France
  4. ‡, Autoimmune Diseases Research and § Department of Cellular and Molecular Pharmacology, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065, USA
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Two genes, ldd-3 and ldd-4, that influence the onset of autoimmune type 1 diabetes in the nonobese diabetic mouse have been located on chromosomes 3 and 11, outside the chromosome 17 major histocompatibility complex. A genetic map of the mouse genome, analysed using the polymerase chain reaction, has been assembled specifically for the study. On the basis of comparative maps of the mouse and human genomes, the homologue of ldd-3 may reside on human chromosomes 1 or 4 and ldd-4 on chromosome 17.