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Close tetrapod relationships of the coelacanth Latimeria indicated by haemoglobin sequences

Abstract

THE origin of tetrapods has been debated for many years. In traditional systematics, the extinct lobe-finned bony fish (Rhipidistia) are regarded as the closest relatives of tetrapods1. Among living fish, the coelacanth Latimeria chalumnae (Actinistia)2–4, which is the only recent representative of the Crossopterygii (Actinistia and Rhipidistia), the lungfish (Dipnoi)5–8 and ray-finned fish (Actinopterygii)9,10, have each been considered as sister-groups of the tetrapods. We have now determined the sequence of the α-and β-globin chains of coelacanth haemoglobin and compared them with all known haemoglobins of bony and cartilaginous fish as well as those of tadpoles and adult amphibians. Haemoglobins of bony fish match more closely those of larval than adult amphibians. The β chains of Latimeria match those of tadpoles more closely (54%) than do those of any other fish, whereas the α chains of Latimeria (45.4%), and especially of teleosts (49.2%), are closer to those of larval amphibians than are those of lungfish (39.8%). If only synapomorphous sequence matches (those at derived positions shared by one bony fish and tadpoles but not by any other bony fish) are considered, both Latimeria globin chains have distinctly more identities with phase of tadpoles than do those of any bony fish. Thus the primary structure of Ii haemoglobin indicates that the coelacanth is the closest living relative of tetrapods.

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References

  1. Romer, A. S. Vergleichende Anatomie der Wirbettiere 4th edn, 37–88 (Parey, Hamburg, Berlin, 1976).

    Google Scholar 

  2. Schultze, H.-P. J. Morph. Suppl. 1, 39–74 (1986).

    Article  Google Scholar 

  3. Long, J. A. J. Vertebr. Paleont. 9, 1–17 (1989).

    Article  Google Scholar 

  4. Nelson, J. S. Fishes of the World 2nd edn (Wiley, New York, 1984).

    Google Scholar 

  5. Benton, M. J. J. molec. Evol. 30, 409–424 (1990).

    Article  ADS  CAS  Google Scholar 

  6. Panchen, A. L. & Smithson, T. R. Biol. Rev. 62, 341–438 (1987).

    Article  Google Scholar 

  7. Rosen, D. E., Forey, P. L., Gardiner, B. G. & Patterson, C. Bull. Am. Mus. nat. Hist. 167, 159–276 (1981).

    Google Scholar 

  8. Forey, P. L. J. Morph. Suppl. 1, 75–91 (1986).

    Article  Google Scholar 

  9. Wahlert, G. von Latimeria und die Geschichte der Wirbeltiere (Fischer, Stuttgart, 1968).

    Google Scholar 

  10. Goodman, M., Miyamoto, M. M. & Czelusniak, J. in Molecules and Morphology in Evolution: Conflict or Compromise? (ed. Patterson, C.) 141–176 (Cambridge University Press, Cambridge, 1987).

    Google Scholar 

  11. Kleinschmidt, T. & Sgouros, J. G. Biol. Chem. Hoppe-Seyler 368, 579–615 (1987).

    Article  CAS  Google Scholar 

  12. Pearson, W. R. & Lipman, D. J. Proc. natn. Acad. Sci. U.S.A. 85, 2444–2448 (1988).

    Article  ADS  CAS  Google Scholar 

  13. Needleman, S. B. & Wunsch, C. D. J. molec. Biol. 48, 443–453 (1970).

    Article  CAS  Google Scholar 

  14. Hosbach, H. A., Wyler, T. & Weber, R. Cell 32, 45–53 (1983).

    Article  CAS  Google Scholar 

  15. Goodman, M., Romero-Herrera, A. E., Dene, H., Czelusniak, J. & Tashian, R. E. in Macromolecular Sequences in Systematic and Evolutionary Biology (ed. Goodman, M.) 115–191 (Plenum, New York, 1982).

    Google Scholar 

  16. Fitch, W. Syst Zool. 19, 99–113 (1970).

    Article  CAS  Google Scholar 

  17. Goodman, M., Moore, G. W. & Matsuda, G. Nature 253, 603–608 (1975).

    Article  ADS  CAS  Google Scholar 

  18. Higgins, D. G. & Sharp, P. M. Gene 73, 237–244 (1988).

    Article  CAS  Google Scholar 

  19. Felsenstein, J. Evolution 39, 783–791 (1985).

    Article  Google Scholar 

  20. Felsenstein, J. Phylip 3.2 Manual (University of California Herbarium, Berkeley, California, 1989).

    Google Scholar 

  21. Hennig, W. Phylogenetic Systematics (University of Illinois Press, Urbana, Chicago, London, 1966).

    Google Scholar 

  22. Ax, P. Das Phylogenetische System (Fischer, Stuttgart, New York, 1984).

    Google Scholar 

  23. Dobzhansky, T., Ayala, F. J., Stebbins, G. L. & Valentine, J. W. Evolution 262–313 (Freeman, San Francisco, 1977).

  24. Felsenstein, J. Syst. Zool. 27, 401–410 (1978).

    Article  Google Scholar 

  25. Felsenstein, J. A. Rev. Ecol. Syst. 14, 313–333 (1983).

    Article  Google Scholar 

  26. Fritzsch, B. Nature 327, 153–154 (1987).

    Article  ADS  CAS  Google Scholar 

  27. Hillis, D. M. & Dixon, M. T. in The Hierarchy of Life-Molecules and Morphology in Phylogenetic Analysis 355–367 (Excerpta Medica, Elsevier, Amsterdam, 1989).

    Google Scholar 

  28. Waehneldt, T. V. & Malotka, J. J. Neurochem. 52, 1941–1943 (1989).

    Article  CAS  Google Scholar 

  29. Watt, K. W. K. & Riggs, A. J. biol. Chem. 250, 5934–5944 (1975).

    CAS  Google Scholar 

  30. Müller, A. H. Lehrbuch der Paläozoologie 2nd edn Vol. 3/1, 194–443 (Fischer, Jena, 1985).

    Google Scholar 

Download references

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Gorr, T., Kleinschmidt, T. & Fricke, H. Close tetrapod relationships of the coelacanth Latimeria indicated by haemoglobin sequences. Nature 351, 394–397 (1991). https://doi.org/10.1038/351394a0

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