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Review
Nature 349, 293-299 (24 January 1991) | doi:10.1038/349293a0
Man-made antibodies
Greg Winter & César Milstein
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Abstract
Monoclonal antibodies can now be genetically engineered and endowed with new properties. In the future, gene technology could enable antigen-binding fragments to be made by exploiting repertoires of variable domain genes derived from immunized animals and expressed in bacteria. How readily can this approach be extended to production of 'in vitro' repertoires of variable domain genes, and obviate the immunization of animals?
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