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Review
Nature 349, 117-127 (10 January 1991) | doi:10.1038/349117a0
The GTPase superfamily: conserved structure and molecular mechanism
Henry R. Bourne, David A. Sanders & Frank McCormick
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Abstract
GTPases are conserved molecular switches, built according to a common structural design. Rapidly accruing knowledge of individual GTPases—crystal structures, biochemical properties, or results of molecular genetic experiments—support and generate hypotheses relating structure to function in other members of the diverse family of GTPases.
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