Nature 348, 600 - 605 (13 December 1990); doi:10.1038/348600a0

Intracellular transport of class II MHC molecules directed by invariant chain

Vincent Lotteau, Luc Teyton, Annick Peleraux, Tommy Nilsson^*, Lars Karlsson, Sandra L. Schmid, Vito Quaranta & Per A Peterson^†

The Department of Immunology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, La Jolla, California 92037, USA
^*Present address: Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX, UK.
^†To whom correspondence should be addressed.

Three structural motifs in the invariant chain (li) control the intracellular transport of class II major histocompatibility complex molecules. An endo-plasmic reticulum retention signal in the full-length li suggests a role for li in the – heterodimer assembly. Another signal motif directs a truncated li, alone or associated with individual class II chains, to a degradation compartment by a pathway circumventing the Golgi. When this truncated li binds – dimers, a third signal dominates, directing the complex by way of the Golgi to vesicles in the cell periphery, which may represent a subcompartment of recycling endosomes.

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