Nature 346, 35 - 39 (05 July 1990); doi:10.1038/346035a0

The protein encoded by the Arabidopsis homeotic gene agamous resembles transcription factors

Martin F. Yanofsky^*, Hong Ma^*, John L. Bowman, Gary N. Drews, Kenneth A. Feldmann^† & Elliot M. Meyerowitz^‡

Division of Biology 156-29, California Institute of Technology, Pasadena, California 91125, USA
^†E. I. DuPont de Nemours and Co., Wilmington, Delaware 19880, USA
^*Present addresses: Department of Biology C-016, University of California at San Diego, La Jolla, California 92093, USA (M.F.Y.) and Cold Spring Harbor Laboratory, P.O. Box 100, Cold Spring Harbor, New York 11724, USA (H.M.).
^‡To whom correspondence should be addressed.

Mutations in the homeotic gene agamous of the plant Arabidopsis cause the transformation of the floral sex organs. Cloning and sequence analysis of agamous suggest that it encodes a protein with a high degree of sequence similarity to the DNA-binding region of transcription factors from yeast and humans and to the product of a homeotic gene from Antirrhinum. The agamous gene therefore probably encodes a transcription factor that regulates genes determining stamen and carpel development in wild-type flowers.

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