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Article
Nature 345, 783-786 (28 June 1990) | doi:10.1038/345783a0; Accepted 18 May 1990
Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID
Keith F. Stringer, C. James Ingles & Jack Greenblatt
- Banting and Best Department of Medical Research and Department of Medical Genetics, University of Toronto, Toronto, Ontario M5G 1L6, Canada
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Abstract
The potent transactivation domain of the herpes simplex virion protein VP16 was used as a column ligand for affinity chromatography. VP16 binds strongly and highly selectively to the human and yeast TATA box-binding factors. Our results imply that the principal target for acidic activation domains is the TATA-box factor TFIID.
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