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Article
Nature 343, 536 - 540 (08 February 1990); doi:10.1038/343536a0

Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels

Paul E. Hardin*, Jeffrey C. Hall & Michael Rosbash*

*Howard Hughes Medical Institute andDepartment of Biology, Brandeis University, Waltham, Massachusetts 02254, USA

Mutations in the period (per) gene of Drosophila melanogaster affect both circadian and ultradian rhythms. Levels of per gene product undergo circadian oscillation, and it is now shown that there is an underlying oscillation in the level of per RNA. The observations indicate that the cycling of per-encoded protein could result from per RNA cycling, and that there is a feedback loop through which the activity of per-encoded protein causes cycling of its own RNA.

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