Nature 342, 385 - 391 (23 November 1989); doi:10.1038/342385a0

Induction of self-tolerance in mature peripheral B lymphocytes

Christopher C. Goodnow, Jeffrey Crosbie, Helle Jorgensen, Robert A. Brink & Antony Basten

Centenary Institute of Cancer Medicine and Cell Biology, University of Sydney, New South Wales 2006, Australia

In transgenic mice, mature peripheral B lymphocytes in lymphoid follicles, like immature B cells, are rendered tolerant by encounter with self-antigen, provided receptor occupancy by self-antigen exceeds a critical threshold. The tolerant state of the B cell is closely correlated with down-regulation of membrane IgM but not IgD antigen-receptors. Identical changes in antigen-receptor expression occur in a subset of follicular B cells in nontransgenic mice, suggesting that clonally silenced self-reactive cells are common in the peripheral B-cell repertoire.

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