| | Opinion |  |
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| | James Baker's brave new world 1
The US Secretary of State is rightly cock-a-hoop about the prospects for arms control in the near future, but his vision of what follows is incomplete. But it is not too soon to be planning for the post-strategic world.
doi:10.1038/342001a0
PDF (119K)
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| | Diplomacy please 1
The US human genome project must be mounted inter-nationally, and others must help pay for it.
doi:10.1038/342001b0
PDF (237K)
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| | Catalogue of errors 2
The British government needs to learn from the way it has damaged its own research enterprise.
doi:10.1038/342002a0
PDF (134K)
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| | News | |
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| | Decline in UK research spending continues 3
Ben Webb
doi:10.1038/342003a0
PDF (136K)
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| | Have grant, will travel 3
Steven Dickman
doi:10.1038/342003b0
PDF (136K)
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| | Officials try to allay fears 4
Seth Shulman
doi:10.1038/342004a0
PDF (152K)
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| | Monsoon prediction model 4
K. S. Jayaraman
doi:10.1038/342004b0
PDF (152K)
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| | Cynics still unsatisfied 5
Seth Shulman
doi:10.1038/342005a0
PDF (153K)
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| | Suit and countersuit for Alaska and Exxon 5
Robert Buderi
doi:10.1038/342005b0
PDF (153K)
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| | UNESCO on trial in Paris 6
Peter Coles
doi:10.1038/342006a0
PDF (151K)
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| | Unions turn green in Australia 6
Tania Ewing
doi:10.1038/342006b0
PDF (151K)
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| | Equivocation on cooperation 7
Christine McGourty
doi:10.1038/342007a0
PDF (172K)
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| | 'Hot lab' to be closed over contamination fears 7
Robert Buderi
doi:10.1038/342007b0
PDF (172K)
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| | Japan agrees to total ban on imports 7
David Swinbanks
doi:10.1038/342007c0
PDF (172K)
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| | Move raises problems 8
Steven Dickman
doi:10.1038/342008a0
PDF (152K)
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| | United stand in move to greater efficiency 8
Ben Webb
doi:10.1038/342008b0
PDF (152K)
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| | New minister, old problems 8
Michael Cherry
doi:10.1038/342008c0
PDF (152K)
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| | Japan under pressure 9
Mike Shaltz
doi:10.1038/342009a0
PDF (152K)
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| | Dupont battles with Cetus 9
Christine McGourty
doi:10.1038/342009b0
PDF (152K)
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| | Lax standards confirmed 10
Vera Rich
doi:10.1038/342010a0
PDF (146K)
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| | Network of centres better than just one 10
Ben Webb
doi:10.1038/342010b0
PDF (146K)
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| | AZT for children in extended US trial 10
David Lindley
doi:10.1038/342010c0
PDF (146K)
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| | Commentary |  |
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| | For unto him that hath... 11
The concept of P-selection, by which graduates of the more prestigious (P) universities tend to publish longer than those from other (NP) universities, is herewith introduced into the literature.
Virginia Trimble
doi:10.1038/342011a0
References | PDF (133K)
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| | Correspondence | |
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| | Criminalization of drugs 12
ANGELA BURR
doi:10.1038/342012a0
PDF (149K)
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| | Collision course 12
ROBERT J. YAES
doi:10.1038/342012b0
PDF (149K)
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| | Stanford scandal 12
ALEX COMFORT
doi:10.1038/342012c0
PDF (149K)
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| | Six of one . . . 12
S. J. GURMAN
doi:10.1038/342012d0
PDF (149K)
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| | News and Views |  |
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| | Mechanical energy from light 13
In principle, it should be possible to turn radiation directly into mechanical energy, but the best designs so far of machines for doing this consist of paper studies. Somebody should build one.
John Maddox
doi:10.1038/342013a0
PDF (146K)
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| | The cell cycle as a cdc2 cycle 14
Andrew W. Murray
doi:10.1038/342014a0
References | PDF (275K)
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| | Variations without forcing 15
Marvin A. Geller
doi:10.1038/342015a0
References | PDF (295K)
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| | Receptor kinships revealed 16
Donald L. Gill
doi:10.1038/342016a0
References | PDF (441K)
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| | Arc volcanism and rifting 18
Kantaro Fujioka
doi:10.1038/342018a0
PDF (440K)
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| | Floodwaters mark sudden rise 20
M. J. Tooley
doi:10.1038/342020a0
References | PDF (327K)
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| | Divided the fruitflies fall 21
Rolf Anker Ims & Nils C. Stenseth
doi:10.1038/342021a0
References | PDF (284K)
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| | Flash and bang 22
David Jones
doi:10.1038/342022a0
PDF (146K)
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| | Scientific Correspondence | |
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| | The unbegun Big Bang 23
JEAN-MARC LÉVY-LEBLOND
doi:10.1038/342023a0
References | PDF (150K)
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| | Frozen Neanderthals 23
PETER MAZUR
doi:10.1038/342023b0
References | PDF (150K)
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| | Transcriptional silencing and lamins 24
JOHN F. X. DIFFLEY & BRUCE STILLMAN
doi:10.1038/342024a0
References | PDF (134K)
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| | Database pollution 24
DAVID R. STANFORD, JOHN T. PENNISTON & ERIC D. WIEBEN
doi:10.1038/342024b0
PDF (134K)
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| | Book Reviews | |
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| | Bulls, bears and bugs 25
Julian Davies reviews Gene Dreams: Wall Street, Academia, and the Rise of Biotechnology
By
Robert Teltelman
doi:10.1038/342025a0
PDF (279K)
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| | DNA in flux 26
J. R. S. Fincham reviews Mobile DNA
By
Douglas E. Berg & Martha M. Howe
doi:10.1038/342026a0
PDF (284K)
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| | Between Tethys and Pacific 27
A. M. C.  engör reviews Geological Evolution of South-East Asia
By
Charles S. Hutchison
doi:10.1038/342027a0
PDF (290K)
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| | Growing pains 28
John de la Mothe reviews E. W. R. Steacle and Science in Canada
By
Christine King
doi:10.1038/342028a0
PDF (155K)
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| | Articles |  |
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| | An analysis of geophysical experiments to test Newton's law of gravity 29
R. L. Parker & M. A. Zumberge
doi:10.1038/342029a0
Abstract & References | PDF (509K)
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| | Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400
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Teiichi Furuichi, Shingo Yoshikawa, Atsushi Miyawaki, Kentaroh Wada, Nobuaki Maeda & Katsuhiko Mikoshiba
doi:10.1038/342032a0
Abstract & References | PDF (780K)
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| | Tyrosine phosphorylation of the fission yeast cdc2
+ protein kinase regulates entry into mitosis 39
Kathleen L. Gould & Paul Nurse
doi:10.1038/342039a0
Abstract & References | PDF (1,134K)
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| | Sequence of an unusually large protein implicated in regulation of myosin activity in C. elegans
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Guy M. Benian, Jane E. Kiff, Nicolas Neckelmann, Donald G. Moerman & Robert H. Waterston
doi:10.1038/342045a0
Abstract & References | PDF (1,058K)
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| | Letters | |
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| | Is Cygnus X-3 blowing bubbles? 51
A. Achterberg
doi:10.1038/342051a0
First paragraph & References | PDF (277K)
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| | Ultra-low-frequency variability in a simple atmospheric circulation model 53
I. N. James & P. M. James
doi:10.1038/342053a0
First paragraph & References | PDF (301K)
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| | Critical currents near 106 A cm-2 at 77 K in neutron-irradiated single-crystal YBa2Cu3O7
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R. B. van Dover, E. M. Gyorgy, L. F. Schneemeyer, J. W. Mitchell, K. V. Rao, R. Puzniak & J. V. Waszczak
doi:10.1038/342055a0
First paragraph & References | PDF (333K)
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| | Water-level fluctuations of Lake Tanganyika in phase with oceanic changes during the last glaciation and deglaciation 57
Franpoise Gasse, Vincent Lédée, Marc Massault & Jean-Charles Fontes
doi:10.1038/342057a0
First paragraph & References | PDF (330K)
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| | Glacial−interglacial climatically forced  13C variations in sedimentary organic matter 60
John P. Jasper & Robert B. Gagosian
doi:10.1038/342060a0
First paragraph & References | PDF (360K)
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| | Sr isotope constraints on the Mediterranean environment at the end of the Messinian salinity crisis 62
M. T. McCulloch & P. De Deckker
doi:10.1038/342062a0
First paragraph & References | PDF (576K)
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| | Hydrothermal oil of Guaymas Basin and implications for petroleum formation mechanisms 65
Borys M. Didyk & Bernd R. T. Simoneit
doi:10.1038/342065a0
First paragraph & References | PDF (492K)
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| | Evidence for anoxygenic photosynthesis from the distribution of bacterio-chlorophylls in the Black Sea 69
D. J. Repeta, D. J. Simpson, B. B. Jorgensen & H. W. Jannasch
doi:10.1038/342069a0
First paragraph & References | PDF (418K)
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| | Distribution of two distinct Ca2+ -ATPase-like proteins and their relationships to the agonist-sensitive calcium store in adrenal chromaff in cells 72
Robert D. Burgoyne, Timothy R. Cheek, Alan Morgan, Antony J. O'Sullivan, Roger B. Moreton, Michael J. Berridge, Ana M. Mata, John Colyer, Anthony G. Lee & J. Malcolm East
doi:10.1038/342072a0
First paragraph & References | PDF (413K)
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| | Inhibition of noradrenaline release by antibodies to B-50 (GAP-43) 74
L. V. Dekker, P. N. E. De Graan, A. B. Oestreicher, D. H. G. Versteeg & W. H. Gispen
doi:10.1038/342074a0
First paragraph & References | PDF (388K)
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| | Production of antibodies in transgenic plants 76
Andrew Hiatt, Robert Caffferkey & Katherine Bowdish
doi:10.1038/342076a0
First paragraph & References | PDF (448K)
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| | Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor 78
David Camerini, Stephen P. James, Ivan Stamenkovic & Brian Seed
doi:10.1038/342078a0
First paragraph & References | PDF (612K)
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| | lnterleukin-2-dependent autocrine proliferation in T-cell development 82
María L. Toribio, José C. Gutiérrez-Ramos, Luis Pezzi, Miguel A. R. Marcos & Carlos Martínez-A
doi:10.1038/342082a0
First paragraph & References | PDF (475K)
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| | A glycophospholipid anchor is required for Qa-2-mediated T cell activation 85
Peter J. Robinson, Margaret Millrain, Jane Antoniou, Elizabeth Simpson & Andrew L. Mellor
doi:10.1038/342085a0
First paragraph & References | PDF (326K)
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| | Purified inositol 1,4,5-trisphosphate receptor mediates calcium flux in reconstituted lipid vesicles 87
Christopher D. Ferris, Richard L. Huganir, Surachai Supattapone & Solomon H. Snyder
doi:10.1038/342087a0
First paragraph & References | PDF (354K)
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| | Nature and site of phospholamban regulation of the Ca2+ pump of sarcoplasmic reticulum 90
P. James, M. Inui, M. Tada, M. Chiesi & E. Carafoli
doi:10.1038/342090a0
First paragraph & References | PDF (360K)
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| | Yeast replication factor-A functions in the unwinding of the SV40 origin of DNA replication 92
Steven J. Brill & Bruce Stillman
doi:10.1038/342092a0
First paragraph & References | PDF (475K)
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| | Induction of the Escherichia coli lactose operon selectively increases repair of its transcribed DNA strand 95
Isabel Mellon & Philip C. Hanawalt
doi:10.1038/342095a0
First paragraph & References | PDF (487K)
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| | Product Reviews | |
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| | Engineering monoclonal antibodies 99
Efforts to alter the mAb component of pharmaceuticals have focused on making them more human-lIke and smaller. Ultimately, the smallest molecular recognition unit derived from antibodies may be a single complementarity region.
J. D. Rodwell
doi:10.1038/342099a0
References | PDF (270K)
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| | Biology's soft cell 100
Highlights at next week's American Society for Cell Biology Annual Meeting in Houston, Texas include an interactive 3-D graphics software package and formuIin-free tissue fixative.
Diane Gershon
doi:10.1038/342100a0
PDF (325K)
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| | EMPLOYMENT | |
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| | Students for higher education 102
The demographic changes predicted for the 1990s may not have the effects that had been expected as there will be a rising proportion of students from non-traditional backgrounds.
Richard Pearson
doi:10.1038/342102a0
PDF (138K)
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