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Recognition of cluster of differentiation 1 antigens by human CD4CD8>− cytolytic T lymphocyte

Abstract

HUMAN cluster-of-differentiation 1 (CD1) is a family of cell surface glycoproteins of unknown function expressed on immature thymocytes, epidermal Langerhans cells and a subset of B lymphocytes1–3. Three homologous proteins, CD la, b and c, have been defined serologically4, and the CD1 gene locus on human chromosome 1 contains five potential CD1 genes5. Analysis of the predicted amino-acid sequences of CD1 molecules reveals a low but significant level of homology to major histocompatibility complex (MHC) class I and class II molecules5,6, and, like MHC class I molecules, CD1 molecules are associated non-covalently with (β2-microglobulin7. These structural similarities to known antigen-presenting molecules, together with the expression of CD1 on cells capable of antigen presentation, suggest a role for CD1 molecules in antigen recognition by T cells. Here we demonstrate the specific recognition of CDla by a CD4CD8 αβ T-cell receptor (TCR) expressing cytolytic T lymphocyte (CTL) line and the specific recognition of CD1c by a CD4CD8>minus; γδTCR CTL line. The interaction of GDI-specific CTLs with CD1+ target cells appeared to involve the CD3–TCR complex, and did not show evidence of MHC restriction. These results suggest that for a subset of T cells, GDI molecules serve a function analogous to that of MHG class I and II molecules.

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References

  1. McMichael, A. J. et al. Eur. J. Immun. 9, 205–210 (1979).

    Article  CAS  Google Scholar 

  2. Fithian, E. et al. Proc. natn. Acad. Sci. U.S.A. 78, 2541–2544 (1981).

    Article  ADS  CAS  Google Scholar 

  3. Small, T. N. et al. J. Immun. 138, 2864–2868 (1987).

    CAS  PubMed  Google Scholar 

  4. Amiot, M. et al. J. Immun. 136, 1752–1758 (1986).

    CAS  PubMed  Google Scholar 

  5. Calabi, F. & Milstein, C. Nature 323, 540–543 (1986).

    Article  ADS  CAS  PubMed  Google Scholar 

  6. Balk, S. P., Bleicher, P. A. & Terhorst, C. Proc. natn. Acad. Sci. U.S.A. 86, 252–256 (1989).

    Article  ADS  CAS  Google Scholar 

  7. Terhorst, C. et al. Cell 23, 771–780 (1981).

    Article  CAS  PubMed  Google Scholar 

  8. Brenner, M. B. et al. Nature 325, 689–694 (1987).

    Article  ADS  CAS  PubMed  Google Scholar 

  9. Jitsukawa, S., Faure, F., Lipinski, M., Triebel, F. & Hercend, T. J. exp. Med. 166, 1192–1197 (1987).

    Article  CAS  PubMed  Google Scholar 

  10. Sleckman, P. P. et al. Nature 328, 351–353 (1987).

    Article  ADS  CAS  PubMed  Google Scholar 

  11. van de Rijn, M. et al. Science 226, 1083–1085 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  12. Santos-Aguado, J., Barbosa, J. A., Biro, P. A. & Strominger, J. L. J. Immun. 141, 2811–2818 (1988).

    CAS  PubMed  Google Scholar 

  13. van Agthoven, A. & Terhorst, C. J. Immun. 128, 426–432 (1982).

    CAS  PubMed  Google Scholar 

  14. Strominger, J. L. Cell 57, 895–898 (1989).

    Article  CAS  PubMed  Google Scholar 

  15. Shivakumar, S., Tsokos, G. C. & Datta, S. K. J. Immun. 143, 103–112 (1989).

    CAS  PubMed  Google Scholar 

  16. Miescher, G. C., Budd, R. C., Lees, R. K. & MacDonald, H. R. J. Immun. 138, 1959–1967 (1987).

    CAS  PubMed  Google Scholar 

  17. Brenner, M. B., Strominger, J. L. & Krangel, M. S. Adv. Immun. 43, 133–192 (1988).

    Article  CAS  PubMed  Google Scholar 

  18. Bluestone, J. A., Cron, R. Q., Cotterman, M., Houlden, B. A. & Matis, L. A. J. exp. Med. 168, 1899–1916 (1988).

    Article  CAS  PubMed  Google Scholar 

  19. Janeway, C. A. Jr, Jones, B. & Hayday, A. C. Immun. Today 6, 73–76 (1988).

    Article  Google Scholar 

  20. Lerch, P. G., van de Rijn, M., Schrier, P. & Terhorst, C. Hum. Immun. 6, 13–30 (1983).

    Article  CAS  PubMed  Google Scholar 

  21. Reinherz, E. R., Kung, P. C., Goldstein, G., Levey, R. H. & Schlossman, S. F. Proc. natn. Acad. Sci. U.S.A. 77, 1588–1592 (1980).

    Article  ADS  CAS  Google Scholar 

  22. Knowles, R. K. & Bodmer, W. F. Eur. J. Immun. 12, 676–681 (1982).

    Article  CAS  Google Scholar 

  23. Martin, L. H., Calabi, F., Lefebvre, F.-A., Bilsland, C. A. G. & Milstein, C. Proc. natn. Acad. Sci. U.S.A. 84, 9189–9193 (1987).

    Article  ADS  CAS  Google Scholar 

  24. Brodsky, F. M. & Parham, P. P. J. Immun. 128, 129–135 (1982).

    CAS  PubMed  Google Scholar 

  25. Spits, H. et al. Hybridoma 2, 423–437 (1983).

    Article  CAS  PubMed  Google Scholar 

  26. Band, H. et al. Science 238, 682–694 (1987).

    Article  ADS  CAS  PubMed  Google Scholar 

  27. Lanier, L. L., Ruitenberg, J. J., Allison, J. P. & Weiss, A. in Leukocyte Typing III (ed. McMichael, A. J.) 175–178 (Oxford University Press, 1987).

    Google Scholar 

  28. Arruffo, A. & Seed, B. J. Immun. 143, 1723–1730 (1989).

    Google Scholar 

  29. de Waal Malefyt, R. et al. J. Immun. 142, 3634–3642 (1989).

    CAS  PubMed  Google Scholar 

  30. Maniatis, T., Fritsch, E. F. & Sambrook, J. Molecular Cloning: A Laboratory Manual (Cold Spring Harbor, New York, 1982).

    Google Scholar 

  31. Potter, H., Weir, L. & Leder P. Proc. natn. Acad. Sci. U.S.A. 81, 7161–7165 (1984).

    Article  ADS  CAS  Google Scholar 

  32. Wigler, M. et al. Cell 16, 777–784 (1979).

    Article  CAS  PubMed  Google Scholar 

  33. Moingeon, P. et al. Nature 339, 312–314 (1989).

    Article  ADS  CAS  PubMed  Google Scholar 

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Porcelli, S., Brenner, M., Greenstein, J. et al. Recognition of cluster of differentiation 1 antigens by human CD4CD8>− cytolytic T lymphocyte. Nature 341, 447–450 (1989). https://doi.org/10.1038/341447a0

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