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Article
Nature 339, 439 - 445 (08 June 1989); doi:10.1038/339439a0

Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor

Hiroshi Takeshima*, Seiichiro Nishimura*, Takeshi Matsumoto*, Hiroyuki Ishida*, Kenji Kangawa, Naoto Minamino, Hisayuki Matsuo, Masamichi Ueda, Masao Hanaoka, Tadaaki Hirose§ & Shosaku Numa*

* Departments of Medical Chemistry and Molecular Genetics, Faculty of Medicine and Department of Pathology, Institute for Virus Research, Kyoto University, Kyoto 606, Japan
Department of Biochemistry, Miyazaki Medical College, Miyazaki 889-16, Japan
§ Pharmaceutical Institute, Keio University School of Medicine, Tokyo 160, Japan

The sequence of 5,037 amino acids composing the ryanodine receptor from rabbit skeletal muscle sarcoplasmic reticulum has been deduced by cloning and sequencing the complementary DNA. The predicted structure suggests that the calcium release channel activity resides in the C-terminal region of the receptor molecule, whereas the remaining portion constitutes the 'foot' structure spanning the junctional gap between the sarcoplasmic reticulum and the transverse tubule.

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