Nature 338, 277 (16 March 1989); doi:10.1038/338277a0

Genomic footprinting with Taq polymerase

H. P. Saluz & J. P. Jost

Friedrich Miescher-lnstitut, PO Box 2543, CH-4002, Basel, Switzerland. For more infor-mation, fill in reader service number 100.

The linear amplification of chemically sequenced DNA with DNA polymerase from Thermus aquatlcus permits the direct detection of DNA methylation and protein−DNA interaction sites in vivo.

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