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A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides

Abstract

Depletion of a subset of 7OK stress proteins in yeast mutants shows that they are involved in the post-translational import of precursor polypeptides into both mitochondria and the lumen of the endoplasmic reticulum. The identification of such a basic function may explain the remarkable evolutionary conservation of the gene family encoding these proteins.

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Deshaies, R., Koch, B., Werner-Washburne, M. et al. A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides. Nature 332, 800–805 (1988). https://doi.org/10.1038/332800a0

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