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Article
Nature 332, 323 - 327 (24 March 1988); doi:10.1038/332323a0

Reshaping human antibodies for therapy

Lutz Riechmann, Michael Clark*, Herman Waldmann* & Greg Winter

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
* Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
Address from April 1988: Department of Molecular Biology, The Research Institute of Scripps Clinic, North Torrey Pines Road, La Jolla, California 02937, USA
To whom correspondence should be addressed.

A human IgGI antibody has been reshaped for serotherapy in humans by introducing the six hypervariable regions from the heavy- and light-chain variable domains of a rat antibody directed against human lymphocytes. The reshaped human antibody is as effective as the rat antibody in complement and is more effective in cell-mediated lysis of human lymphocytes.

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