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A novel viral oncogene with structural similarity to phospholipase C

Nature volume 332, pages 272–275 (1988)Cite this article

Abstract

Numerous oncogenes have been isolated from acutely transforming retroviruses. To date, the products of these viral oncogenes have been protein kinases, nuclear proteins, growth factors, or GTP-binding proteins1,2. We have cloned the previously uncharacterized avian sarcoma virus CT10 and sequenced its genome. This virus encodes a protein, p47gag-crk, that has blocks of sequence similarity to the amino-terminal, non-catalytic region of the non-receptor class of tyrosine kinases. In addition, the structure of p47gag-crk has striking similarity to a 180-amino acid region of bovine brain phospholipase C. Biochemical data suggest that p47gag-crk activates one or several endogenous tyrosine kinases.

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Authors and Affiliations

  1. The Rockefeller University, New York, New York, 10021, USA

    Bruce J. Mayer, Michinari Hamaguchi & Hidesaburo Hanafusa

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  1. Bruce J. Mayer
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  2. Michinari Hamaguchi
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  3. Hidesaburo Hanafusa
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Mayer, B., Hamaguchi, M. & Hanafusa, H. A novel viral oncogene with structural similarity to phospholipase C. Nature 332, 272–275 (1988). https://doi.org/10.1038/332272a0

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