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Article
Nature 324, 635 - 640 (18 December 1986); doi:10.1038/324635a0

The c-erb-A protein is a high-affinity receptor for thyroid hormone

Jan Sap*, Alberto Muñoz*, Klaus Damm*, Yves Goldberg, Jacques Ghysdael, Achim Leutz*, Hartmut Beug* & Björn Vennström*

*Differentiation Programme, European Molecular Biology Laboratory, Postfach 10.2209, D-6900 Heidelberg, FRG
INSERM, Pasteur Institute, 15 Rue Guerin, 59019 Lille Cedex, France
Present address: Department of Microbiology, State University of New York at Stony Brook, Stony Brook, New York 11790, USA.

Hormone binding and localization of the c-erb-A protein suggest that it is a receptor for thyroid hormone, a nuclear protein that binds to DNA and activates transcription. In contrast, the product of the viral oncogene v-erb-A is defective in binding the hormone but is still located in the nucleus.

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References

1. Frykberg, L. et al. Cell 32, 227−238 (1983). | Article | PubMed | ISI | ChemPort |
2. Kahn, P. et al. Cell 45, 349−356 (1986). | Article | PubMed | ISI | ChemPort |
3. Damm, K., Beug, H., Graf, T. & Vennstrüm, B. EMBO J. (submitted).
4. Weinberger, C., Hollenberg, S. M., Rosenfeld, M. G. & Evans, R. M. Nature 318, 670−672 (1985). | Article | PubMed | ISI | ChemPort |
5. Green, S. et al. Nature 320, 134−139 (1986). | Article | PubMed | ISI | ChemPort |
6. Krust, A. et al. EMBO J. 5, 891−897 (1986). | PubMed | ISI | ChemPort |
7. Conneely, O. M. et al. Science 233, 767−770 (1986). | PubMed | ISI | ChemPort |
8. Oppenheimer, J. H. & Samuels, H. H. (eds) Molecular Basis of Thyroid Hormone Action (Academic, New York, 1983).
9. Vennström, B. & Bishop, J. M. Cell 28, 135−143 (1982). | Article | PubMed | ISI | ChemPort |
10. Watson, C. J. & Jackson, J. F. in DNA cloning (ed. Glover, D. M.) Vol. 1, 79−88 (IRL, Oxford, 1985).
11. Young, R. A. & Davis, R. W. Proc. natn. Acad. Sci. U.S.A. 80, 1194−1198 (1983) | ChemPort |
12. Debuire, B. et al. Science 224, 1456−1459 (1984). | PubMed | ISI | ChemPort |
13. Schwartz, D. E., Tizard, R. & Gilbert, W. Cell 32, 853−869 (1983). | Article | PubMed | ISI | ChemPort |
14. Analects 13, 1−2 (Pharmacia, Uppsala, 1986).
15. Mulligan, R. C. & Berg, P. Science 209, 1422−1427 (1980). | PubMed | ISI | ChemPort |
16. Pascual, A., Casanova, J. & Samuels, H. H. J. biol Chem. 257, 9640−9647 (1985).
17. Dozin, B., Cahnmann, H. J. & Nikodem, V. M. Biochemistry 24, 5197−5202 (1982).
18. Inoue, A., Yamakawa, J., Yakioka, M. & Morisawa, S. Analyt. Biochem. 134, 176−183 (1983). | PubMed | ISI | ChemPort |
19. Samuels, H. H., Stanley, F. & Casanova, J. J. clin. Invest. 63, 1229−1240 (1979). | PubMed | ISI | ChemPort |
20. Samuels, H. H., Tsai, H. S. & Casanova, J. Science 184, 1188−1191 (1974). | PubMed | ISI | ChemPort |
21. Oppenheimer, J. H. in Molecular Basis of Thyroid Hormone Action (eds Oppenheimer, J. H. & Samuels, H. H.) 1−34 (Academic, New York, 1983).
22. Latham, K. R., Ring, J. C. & Baxter, J. D. J. biol. Chem. 251, 7388−7397 (1976). | PubMed | ISI | ChemPort |
23. Scatchard, G. Ann. N.Y. Acad. Sci. 51, 660−672 (1949). | ChemPort |
24. Seelig, S., Schwartz, H. L. & Oppenheimer, J. H. J. biol. Chem. 256, 2154−2161 (1981). | PubMed | ISI | ChemPort |
25. Samuels, H. H. in Molecular Biology of Thyroid Hormone Action (eds Oppenheimer, J. H. & Samuels, H.) 36−65 (Academic, New York, 1983).
26. Kumar, V., Green, S., Staus, A. & Chambom, P. EMBO J. 5, 2231−2236 (1986). | PubMed | ISI | ChemPort |
27. Hughes, S. & Kosik, E. Virology 136, 89−99 (1984). | Article | PubMed | ISI | ChemPort |
28. Samuels, H. H., Stanley, F. & Shapiro, L. E. Proc. natn. Acad. Sci. U.S.A. 73, 3877−3881 (1976). | ChemPort |
29. Samuels, H. H., Stanley, F. & Shapiro, L. E. J. biol. Chem. 252, 6052−6060 (1977). | PubMed | ISI | ChemPort |
30. Bunte, T., Greiser-Wilke, I., Donner, P. & Mölling, K. EMBO J. 1, 919−927 (1982). | PubMed | ISI | ChemPort |
31. King, W. J. & Greene, G. L. Nature 302, 745−747 (1984).
32. Welshons, W. V., Liebermann, M. E. & Gorski, J. Nature 307, 747−749 (1984). | PubMed | ISI | ChemPort |
33. Weinberger, C. et al. Nature 324 641−646 (1986). | Article | PubMed | ISI | ChemPort |
34. Wilson, J. D. & Foster, D. W. (eds) Williams' Textbook of Endocrinology (Saunders, Philadelphia, 1985).
35. Jansson, M., Philipson, L. & Vennström, B. EMBO J. 2, 561−565 (1983). | PubMed | ISI | ChemPort |
36. Spurr, N. et al. EMBO J. 3, 159−163 (1984). | PubMed | ISI | ChemPort |
37. Dayton, A. et al. Proc. natn. Acad. Sci. U.S.A. 81, 4495−4499 (1984). | ChemPort |
38. Zabel, B. U. et al. Proc. natn. Acad. Sci. U.S.A. 81, 4874−4878 (1984). | ChemPort |
39. Macleod, K. M. & Baxter, J. D. J. biol. Chem. 251, 7380−7387 (1976). | PubMed | ISI | ChemPort |
40. Wilson, B. D., Wium, C. A. & Gent, W. L. Biochem. biophys. Res. Commun. 124, 29−36 (1984). | PubMed | ISI | ChemPort |
41. Yamamoto, K. A. A. Rev. Genet. 19, 209−252 (1985). | Article | ISI | ChemPort |
42. Fukuda, M., Fukuda, M. N., Papayannopoulou, T. & Hakomori, S-I. Proc. natn. Acad. Sci. U.S.A. 77, 3474−3478 (1980). | ChemPort |
43. Mager, D. & Bernstein, A. J. cell. Physiol. 100, 467−480 (1979). | PubMed | ISI | ChemPort |
44. Sassa, S., Bradlow, H. L. & Kappas, A. J. biol. Chem. 254, 10011−10020 (1979). | PubMed | ChemPort |
45. Lo, C-S. & Edelman, I. S. J. biol. Chem. 251, 7834−7840 (1976). | PubMed | ISI | ChemPort |
46. Lo, C-S. & Lo, T. N. J. biol. Chem. 255, 2132−2136 (1980).
47. Guernsey, D. L., Borek, C., Fisher, P. B. & Edelman, I. S. in Genes and Proteins in Oncogenesis (eds Weinstein, I. B. & Vogel, H. J.), (Academic, New York, 1983).
48. Fisher, P. B., Guernsey, D. L., Weinstein, I. B. & Edelman, I. S. Proc. natn. Acad. Sci. U.S.A. 80, 196−200 (1983). | ChemPort |
49. Dejean, A., Bougueleret, L., Grzeschik, K.-H. & Tiollais, P. Nature 322, 70−72 (1986). | Article | PubMed | ISI | ChemPort |
50. Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 475−477 (1977).
51. Hayman, M. et al. Cell 32, 579−588 (1983). | Article | PubMed | ISI | ChemPort |
52. Graham, F. L. & van der Eb, A. J. Virology 52, 456−467 (1973). | Article | PubMed | ISI | ChemPort |
53. Stow, N. D. & Wilkie, N. W. J. gen. Virol. 33, 447−453 (1976). | PubMed | ISI | ChemPort |
54. Samuels, H. H., Stanley, F. & Casanova, J. Endocrinology 105, 80−85 (1978). | ISI |
55. Samuels, H. H. & Tsai, J. S. Proc. natn. Acad. Sci. U.S.A. 70, 3488−3492 (1973). | ChemPort |



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