Nature Publishing Group, publisher of Nature, and other science journals and reference works
Nature
my account e-alerts subscribe register
   
Tuesday 17 October 2017
Journal Home
Current Issue
AOP
Archive
Download PDF
References
Export citation
Export references
Send to a friend
More articles like this

Letters to Nature
Nature 324, 367 - 369 (27 November 1986); doi:10.1038/324367a0

Sulphonolipids are molecular determinants of gliding motility

Darren R. Abbanat, Edward R. Leadbetter, Walter  Godchaux III & Alan Escher

Department of Molecular and Cell Biology, U-131, University of Connecticut, Storrs, Connecticut 06268, USA

A variety of bacteria1 that possess no obvious locomotor organelles are, nonetheless, able to translocate on solid surfaces (but not through liquids). In no case has the mechanism of this ‘gliding’ motility been elucidated2. Our recent discovery that unusual sulphonolipids3,4 (Fig. 1) are major cell-envelope components peculiar to the Cytophaga-Flexibacter group of gliding bacteria5 led us to examine whether these lipids are important in this motility. Mutants deficient in both gliding and sulphonolipid synthesis were isolated from mutagenized cultures of Cytophaga johnsonae (our laboratory strain, originally ATCC 17061). In some of these mutants, restoration of sulphonolipid content through provision of a specific biosynthetic precursor resulted in recovery of the ability to glide. The sulphonolipids are the first molecules shown to be specifically required for gliding motility (surface translocation).

------------------

References

1. Reichenbach, H. A. Rev. Microbiol. 35, 339−364 (1981). | Article | ISI | ChemPort |
2. Burchard, R. P. A. Rev. Microbiol. 35, 497−529 (1981). | Article | ISI | ChemPort |
3. Godchaux, W. & Leadbetter, E. R. J. Bact. 144, 592−602 (1980). | PubMed | ISI | ChemPort |
4. Godchaux, W. & Leadbetter, E. R. J. boil. Chem. 259, 2982−2990 (1984). | ChemPort |
5. Godchaux, W. & Leadbetter, E. R. J. Bact. 153, 1238−1246 (1983). | PubMed | ISI | ChemPort |
6. Abbanat, D. R., Godchaux, W., Polychroniou, G. & Leadbetter, E. R. Biochem. biophys. Res. Commun. 130, 873−878 (1985). | PubMed | ISI | ChemPort |
7. Brady, R. O. & Koval, G. O. J. biol. Chem. 233, 26−31 (1958). | PubMed | ISI | ChemPort |
8. Chang, L.-Y. E., Pate, J. L. & Betzig, R. O. J. Bact. 159, 26−35 (1984). | PubMed | ISI | ChemPort |
9. Pate, J. L. & Chang, L.-Y. E. Curr. Microbiol. 2, 59−64 (1979). | ISI |
10. Wolkin, R. H. & Pate, J. L. J. gen. Microbiol. 131, 737−750 (1985). | ISI |
11. Lapidus, I. R. & Berg, H. C. J. Bact. 151, 384−398 (1982). | PubMed | ISI | ChemPort |



© 1986 Nature Publishing Group
Privacy Policy