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Article
Nature 321, 406 - 411 (22 May 1986); doi:10.1038/321406a0

Molecular distinction between fetal and adult forms of muscle acetylcholine receptor

Masayoshi Mishina, Toshiyuki Takai, Keiji Imoto, Masaharu Noda, Tomoyuki Takahashi*, Shosaku Numa, Christoph Methfessel & Bert Sakmann

Departments of Medical Chemistry and Molecular Genetics and *Physiology, Kyoto University Faculty of Medicine, Kyoto 606, Japan
Max-Planck-Institut für biophysikalische Chemie, D-3400 Göttingen, FRG

Distinct classes of acetylcholine receptor channels are formed when Xenopus oocytes are injected with combinations of the bovine α-, β-, γ- and δ- or the α-, β-, γ- and ε-subunit-specific messenger RNAs. The conductance and gating properties of the two classes of channels, in conjunction with the developmental changes in the muscular contents of the mRNAs, suggest that replacement of the γ-subunit by the ε-subunit is responsible for the functional alteration of the receptor during muscle development.

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