Nature 321, 219 - 226 (15 May 1986); doi:10.1038/321219a0

Correlations between T-cell specificity and the structure of the antigen receptor

Pamela J. Fink^*, Louis A. Matis^†, David L. McElligott^*, Michael Bookman^† & Stephen M. Hedrick^*

^*Department of Biology, Cancer Center, M-001, University of California, San Diego, La Jolla, California 92093, USA. ^†Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.

The derived amino-acid sequences of the heterodimeric antigen receptors expressed by a series of murine T-cell clones are presented. A comparison of the receptor sequences indicates that several mechanisms for generating receptor diversity can influence T-cell specificity, including junctional diversity, combinatorial joining, and combinatorial chain associations.

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