Nature 319, 121 - 126 (09 January 1986); doi:10.1038/319121a0

Requirement of stereospecific alignments for initiation from the simian virus 40 early promoter

Keikichi Takahashi^*, Marc Vigneron^*, Hans Matthes, Alan Wildeman^*, M. Zenke^* & Pierre Chambon

Laboratoire de Génétique Moléculaire des Eucaryotes, CNRS, Unité 184 de Biologie Moléculaire et de Génie Génétique, INSERM, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg 67085 Cédex, France
^*Present addresses: Medical Institute for Bioregulation, Kyushu University, Maedashi 3-1-1, Higashi-ku, Fukuoka 812, Japan (K.T.); Department of Virology, The Weizmann Institute for Science, Rehovot, Israel (M.V.); Department of Molecular Biology and Genetics, University of Guelph, Guelph, Ontario, Canada NIG 2W1 (A.W.); European Molecular Biology Laboratory, Postfach 102209, D-6900 Heidelberg, FRG (M.Z.).

The distance between the simian virus 40 early promoter elements has been altered by inserting either odd or even multiples of half a DNA turn. There are marked differences in the in vivo effects of these two types of insertions on initiation of transcription from this promoter.

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