Nature 316, 596 - 601 (15 August 1985); doi:10.1038/316596a0

A phage repressor−operator complex at 7 Å resolution

John E. Anderson, Mark Ptashne & Stephen C. Harrison

Department of Biochemistry and Molecular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA

The crystal structure of a complex between the DNA-binding domain of phage 434 repressor and a synthetic 434 operator shows that the protein, very similar in conformation to repressor, binds to B-form DNA with the second -helix of a helix−turn−helix motif lying in the major groove.

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