| | Opinion |  |
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| | Where next after Geneva break? 281
The Geneva arms control talks have adjourned without breaking down, which is something to be grateful for. The negotiators should spend their break deciding where to go from here.
doi:10.1038/316281a0
PDF (125K)
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| | Reaganomics found out 281
The US economy is heading for stagnation and the need to cut the deficit is more urgent.
doi:10.1038/316281b0
PDF (266K)
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| | University on brink 282
The changed University of London could be fun to watch.
doi:10.1038/316282a0
PDF (144K)
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| | News | |
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| | Defence research: Defence to support UK academic research 283
Phillip Campbell
doi:10.1038/316283a0
PDF (141K)
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| | University of Geneva: Illmensee's view 283
Peter Newmark
doi:10.1038/316283b0
PDF (141K)
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| | Genetic engineering patents: Interferon interference 283
Peter Newmark
doi:10.1038/316283c0
PDF (141K)
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| | Space business: Suppliers ready to break rules 284
doi:10.1038/316284a0
PDF (140K)
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| | US pharmaceuticals: Monsanto and Searle to merge 284
John Maddox
doi:10.1038/316284b0
PDF (140K)
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| | Academic innovation: Cambridge science park succeeds 285
Elizabeth Collins
doi:10.1038/316285a0
PDF (141K)
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| | UK laboratory animals: Experimentation reduced 286
Maxine Clarke
doi:10.1038/316286a0
PDF (134K)
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| | US animal rights 286
Stephen Budiansky
doi:10.1038/316286b0
PDF (134K)
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| | UK laboratory animals: Experimentation reduced 286
Maxine Clarke
doi:10.1038/316286c0
PDF (134K)
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| | Framatome: French company still adrift 286
Robert Walgate
doi:10.1038/316286d0
PDF (134K)
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| | French information: New centre for Nancy 287
Robert Walgate
doi:10.1038/316287a0
PDF (136K)
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| | West Germany: Support for biotechnology 287
Jürgen Neffe
doi:10.1038/316287b0
PDF (136K)
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| | More pork-barrel politics 287
Stephen Budiansky
doi:10.1038/316287c0
PDF (136K)
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| | Bhopal: Birth defect fears allayed 288
K. S. Jayaraman
doi:10.1038/316288a0
PDF (131K)
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| | Eureka: Party launches agenda only 288
Robert Walgate
doi:10.1038/316288b0
PDF (131K)
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| | Poland: Environment at long-term risk 289
Vera Rich
doi:10.1038/316289a0
PDF (137K)
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| | Soil Survey: Budget squeeze hurts projects 289
doi:10.1038/316289b0
PDF (137K)
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| | Correspondence | |
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| | Pain and laboratory animals 290
ROBERT SHARPE
doi:10.1038/316290a0
PDF (131K)
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| | Romanian reactors 290
A. I. SMITH
doi:10.1038/316290b0
PDF (131K)
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| | The nose knows 290
JOHN HARTUNG
doi:10.1038/316290c0
PDF (131K)
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| | Safety cabinets 290
K. MCCARTHY
doi:10.1038/316290d0
PDF (131K)
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| | News and Views |  |
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| | Why celebrate laser birthday? 291
Lasers were first constructed 25 years ago. An historical account and some recent work appear in this issue. There can hardly ever have been an instrument that so quickly became pervasive.
John Maddox
doi:10.1038/316291a0
PDF (133K)
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| | Muscle contraction: Weak and strong crossbridges 292
Malcolm Irving
doi:10.1038/316292a0
References | PDF (266K)
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| | A crossbridge too far ......? 292
Malcolm Irving
doi:10.1038/316292b0
PDF (132K)
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| | Structural geology: To stretch a continent 293
I. R. Vann
doi:10.1038/316293a0
PDF (278K)
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| | Infrared astronomy: Views across the Galaxy 294
Charles Beichman
doi:10.1038/316294a0
PDF (468K)
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| | 100 years ago 295
doi:10.1038/316295a0
PDF (190K)
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| | Infrared astronomy: Views outside the Galaxy 296
Martin Ward
doi:10.1038/316296a0
PDF (275K)
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| | Solid-state chemistry: Topotaxy in metal-oxide reduction 297
Robert W. Cahn
doi:10.1038/316297a0
References | PDF (141K)
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| | Plant ecology: Fertile arguments in the desert 298
Jonathan Silvertown
doi:10.1038/316298a0
References | PDF (148K)
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| | Excitation-contraction coupling: The messenger across the gap 298
Andrew P. Somlyo
doi:10.1038/316298b0
References | PDF (339K)
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| | Laser physics: Advances in free-electron lasers 300
M. W. Poole
doi:10.1038/316300a0
PDF (137K)
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| | Scientific Correspondence | |
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| | Pesticides and the decline of Guam's native birds 301
CHRISTIAN E. GRUE
doi:10.1038/316301a0
References | PDF (139K)
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| | Pesticides and the decline of Guam's native birds 301
J. SAVIDGE
doi:10.1038/316301b0
References | PDF (139K)
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| | Electrostatics revindicated ... classically ... 301
R. NITYANANDA
doi:10.1038/316301c0
References | PDF (139K)
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| | ... by conducting ellipsoid 301
A. M. CORMACK
doi:10.1038/316301d0
References | PDF (257K)
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| | ... with charged polygons 302
R. A. NAUMANN
doi:10.1038/316302a0
PDF (121K)
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| | ... but for 12 equal point charges? 302
STEVE WEBB
doi:10.1038/316302b0
PDF (121K)
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| | Book Reviews |  |
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| | The rise of 'Mobilism' 303
Roy Porter reviews The Dark Side of the Earth. The Battle for the Earth Sciences: 1800-1980.
By
Robert Muir Wood
doi:10.1038/316303a0
PDF (133K)
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| | Getting down to the bare bones 304
Richard Potts reviews The Analysis of Animal Bones from Archeological Sites.
By
Richard G. Klein & Kathryn Cruz-Uribe
doi:10.1038/316304a0
PDF (126K)
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| | The wonderful sky at night 304
Martin Harwit reviews The Cambridge Atlas of Astronomy.
By
Jean Audouze & Guy Isräel
doi:10.1038/316304b0
PDF (126K)
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| | The unseen revealed 305
A. Howie reviews The Beginnings of Electron Microscopy.
Edited by
Peter W. Hawkes
doi:10.1038/316305a0
PDF (156K)
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| | Plumbing the depths 305
Stephen Moorbath reviews Archaean Geochemistry: The Origin and Evolution of the Archaean Continental Crust.
Edited by
A. Krüner, G. N. Hanson & A. M. Goodwin
doi:10.1038/316305b0
PDF (293K)
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| | News and Views | |
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| | Animal cognition 306
Geoffrey Hall reviews Animal Intilligence.
Edited by
L. Weiskrantz
doi:10.1038/316106a0
PDF (140K)
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| | Lasers Review | |
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| | Birth of the maser and laser 307
doi:10.1038/316307a0
Abstract & References | PDF (368K)
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| | Kastler's views on Pauli's contribution 308
doi:10.1038/316308a0
PDF (137K)
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| | High-power solid-state lasers 309
J. F. Holzrichter
doi:10.1038/316309a0
Abstract & References | PDF (755K)
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| | Laboratory production of X-ray lasers 314
M. H. Key
doi:10.1038/316314a0
Abstract & References | PDF (687K)
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| | Lasers, nonlinear optics and optical computers 319
S. D. Smith
doi:10.1038/316319a0
Abstract & References | PDF (680K)
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| | Laser biology and medicine 325
V. S. Letokhov
doi:10.1038/316325a0
Abstract & References | PDF (749K)
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| | Article |  |
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| | Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism 330
Alex Koufos, Marc F. Hansen, Neal G. Copeland, Nancy A. Jenkins, Beatrice C. Lampkin & Webster K. Cavenee
doi:10.1038/316330a0
Abstract & References | PDF (649K)
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| | Letters | |
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| | Crystallographically aligned metal−oxide composite made by reduction of a directionally solidified oxide−oxide eutectic 335
A. Revcolevschi & G. Dhalenne
doi:10.1038/316335a0
First paragraph & References | PDF (345K)
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| | Continental volume and freeboard through geological time 336
G. Schubert & A. P. S. Reymer
doi:10.1038/316336a0
First paragraph & References | PDF (666K)
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| | Sea-bed noises reveal role of turbulent bursting phenomenon in sediment transport by tidal currents 339
A. D. Heathershaw & P. D. Thorne
doi:10.1038/316339a0
First paragraph & References | PDF (389K)
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| | Hydrothermal particle plumes over the southern Juan de Fuca Ridge 342
Edward T. Baker, J. William Lavelle & Gary J. Massoth
doi:10.1038/316342a0
First paragraph & References | PDF (308K)
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| | Acetylcholine activates an inward current in single mammalian smooth muscle cells 345
C. D. Benham, T. B. Bolton & R. J. Lang
doi:10.1038/316345a0
First paragraph & References | PDF (356K)
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| | Inositol 1,4,5-trisphosphate induces calcium release from sarcoplasmic reticulum of skeletal muscle 347
Pompeo Volpe, Giovanni Salviati, Francesco Di Virgilio & Tullio Pozzan
doi:10.1038/316347a0
First paragraph & References | PDF (364K)
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| | Mapping of general anaesthetic target sites provides a molecular basis for cutoff effects 349
N. P. Franks & W. R. Lieb
doi:10.1038/316349a0
First paragraph & References | PDF (364K)
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| | Tissue-specific modulation of a set of related cell surface antigens in Drosophila
351
Michael Wilcox & Maria Leptin
doi:10.1038/316351a0
First paragraph & References | PDF (596K)
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| | Specific targeting of cytotoxic T cells by anti-T3 linked to anti-target cell antibody 354
Pilar Perez, Robert W. Hoffman, Stephen Shaw, Jeffrey A. Bluestone & David M. Segal
doi:10.1038/316354a0
First paragraph & References | PDF (361K)
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| | Pre-B cells in  -transgenic mice 356
Ursula Storb, Kathleen A. Denis, Ralph L. Brinster & Owen N. Witte
doi:10.1038/316356a0
First paragraph & References | PDF (385K)
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| | A transposon-like element in human DNA 359
K. Eric Paulson, Niren Deka, Carl W. Schmid, Ravi Misra, Christian W. Schindler, Mark G. Rush, Lisa Kadyk & Leslie Leinwand
doi:10.1038/316359a0
First paragraph & References | PDF (384K)
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| | Lymphokine dependence of in vivo expression of MHC class II antigens by endothelium 361
G. Groenewegen, W. A. Buurman & C. J. van der Linden
doi:10.1038/316361a0
First paragraph & References | PDF (723K)
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| | Subtle structural alterations in the chains of type I procollagen produce osteogenesis imperfecta type II 363
Jeffrey Bonadio & Peter H. Byers
doi:10.1038/316363a0
First paragraph & References | PDF (597K)
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| | Sliding distance of actin filament induced by a myosin crossbridge during one ATP hydrolysis cycle 366
Toshio Yanagida, Toshiaki Arata & Fumio Oosawa
doi:10.1038/316366a0
First paragraph & References | PDF (524K)
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| | Alterations of the hprt gene in human in vivo-derived 6-thioguanine-resistant T lymphocytes 369
Richard J. Albertini, J. Patrick O'Neill, Janice A. Nicklas, Nicholas H. Heintz & Philip C. Kelleher
doi:10.1038/316369a0
First paragraph & References | PDF (392K)
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| | A hybrid recognition sequence in a recombinant restriction enzyme and the evolution of DNA sequence specificity 371
Valakunja Nagaraja, John C. W. Shepherd & Thomas A. Bickle
doi:10.1038/316371a0
First paragraph & References | PDF (291K)
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| | Product Reviews | |
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| | The laser — hero or villain? 373
Although too often associated in people's minds with star wars weaponry the laser has become an invaluable tool in many varied and peaceful applications.
Bridget Marx
doi:10.1038/316373a0
PDF (250K)
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| | Lasers in commercial applications 374
A user-group based at Culham gives access to high-power lasers, and laser Raman microscopy is becoming established.
doi:10.1038/316374a0
PDF (670K)
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| | Books Received | |
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| | Books Received 377
doi:10.1038/316377a0
PDF (286K)
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