Nature 314, 441 - 443 (04 April 1985); doi:10.1038/314441a0

Presynaptic neurones may contribute a unique glycoprotein to the extracellular matrix at the synapse

Pico Caroni, Steven S. Carlson, Erik Schweitzer & Regis B. Kelly

Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, USA

As the extracellular matrix at the original site of a neuromuscular junction seems to play a major part in the specificity of synaptic regeneration¹⁻⁵, considerable attention has been paid to unique molecules localized to this region⁶⁻¹¹. Here we describe an extracellular matrix glycoprotein of the elasmobranch electric organ that is localized near the nerve endings. By immunological criteria, it is synthesized in the cell bodies, transported down the axons and is related to a glycoprotein in the synaptic vesicles of the neurones that innervate the electric organ. It is apparently specific for these neurones, as it cannot be detected elsewhere in the nervous system of the fish. Therefore, neurones seem to contribute unique extracellular matrix glycoproteins to the synaptic region. Synaptic vesicles could be involved in transporting these glycoproteins to or from the nerve terminal surface.

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