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Structure of the calcium regulatory muscle protein troponin-C at 2.8 Å resolution

Nature volume 313, pages 653–659 (1985)Cite this article

Abstract

Crystals of turkey skeletal muscle troponin-C reveal a molecule of two domains with an unusual structure. Two Ca2+ ions are bound to the C-terminal domain. The two cation-binding sites of the regulatory (N-terminal) domain are Ca2+ free; this domain adopts a markedly different conformation from the C-terminal domain. The two domains are connected by a long nine-turn α-helix; three of these turns are exposed fully to solvent.

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Authors and Affiliations

  1. MRC of Canada Group in Protein Structure and Function, Department of Biochemistry, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada

    Osnat Herzberg & Michael N. G. James

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  1. Osnat Herzberg
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  2. Michael N. G. James
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Herzberg, O., James, M. Structure of the calcium regulatory muscle protein troponin-C at 2.8 Å resolution. Nature 313, 653–659 (1985). https://doi.org/10.1038/313653a0

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