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Article
Nature 312, 517-520 (6 December 1984) | doi:10.1038/312517a0; Accepted 25 September 1984
Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in 
transgenic mice
Kindred A. Ritchie, Ralph L. Brinster* & Ursula Storb
- Department of Microbiology and Immunology, School of Medicine, University of Washington, Seattle, Washington 98195 and *Laboratory of Reproductive Physiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
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Abstract
Hybridomas were produced from spleen cells of 
transgenic mice to investigate expression of the transgenic gene, its effect on allelic exclusion and its effect on the control of light-chain gene rearrangement and expression. Our results show that the transgene is expressed normally and that the production of a complete immunoglobulin molecule turns off light-chain gene rearrangement.
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