| | Opinion |  |
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| | What will happen to UNESCO? 293
The British Government seems about to follow the United States into resignation from UNESCO. That will not be the end of the world (or even of UNESCO).
doi:10.1038/312293a0
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| | News | |
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| | Fifth generation computers: Japan finds rivals treading uncomfortably close 295
Alun Anderson
doi:10.1038/312295a0
PDF (141K)
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| | Apartheid telescoped 295
Philip Campbell
doi:10.1038/312295b0
PDF (141K)
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| | US research objectives: Keyworth's shopping list 296
Tim Beardsley
doi:10.1038/312296a0
PDF (140K)
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| | Australian pests: Legal framework for control 296
Jeffrey Sellar
doi:10.1038/312296b0
PDF (140K)
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| | European computing: French bid to build centre 297
Robert Walgate
doi:10.1038/312297a0
PDF (144K)
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| | NIH: Academy recommends guile 297
Stephen Budiansky
doi:10.1038/312297b0
PDF (144K)
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| | Whaling: US and Japan agree to disagree 298
Alun Anderson
doi:10.1038/312298a0
PDF (155K)
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| | Around the world in four years 298
Peta Pickering
doi:10.1038/312298b0
PDF (155K)
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| | Vaccinia virus: WHO to back vector vaccines 299
Tim Beardsley
doi:10.1038/312299a0
PDF (141K)
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| | Israeli education: Palestinians push ahead 299
Nechemia Meyers
doi:10.1038/312299b0
PDF (141K)
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| | Gromyko's prize 299
Vera Rich
doi:10.1038/312299c0
PDF (141K)
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| | United states in UNESCO: Withdrawal sanctioned by default 300
Tim Beardsley
doi:10.1038/312300a0
PDF (136K)
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| | West German forests: Damage survey looks bad 300
L.W. Blank
doi:10.1038/312300b0
PDF (136K)
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| | Correspondence | |
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| | Conditions for disarmament 301
R.I.P. BULKELEY
doi:10.1038/312301a0
PDF (150K)
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| | Conditions for disarmament 301
DAVID LOWRY
doi:10.1038/312301b0
PDF (150K)
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| | Family planning 301
STEVEN L. MARCUS
doi:10.1038/312301c0
References | PDF (150K)
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| | Moral responsibility 302
PHILIP SIEKEVITZ
doi:10.1038/312302a0
PDF (141K)
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| | Red Sirius 302
R.H. VAN GENT
doi:10.1038/312302b0
References | PDF (141K)
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| | Italian slur rebutted 302
Lucio LUZZATTO
doi:10.1038/312302c0
PDF (141K)
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| | Italian slur rebutted 302
FRANCESCO IZZO
doi:10.1038/312302d0
PDF (141K)
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| | Commentary |  |
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| | Genetic engineering and pharmaceuticals 303
Genetic engineering now allows biological synthesis and large-scale production of several proteins with therapeutic potential. The principal challenge in this sphere is to identify new, medically and commercially significant targets — the province of cell biologists, physiologists and biochemists. In the future, genetic engineering will surely provide invaluable tools for the study of the molecular basis of cellular control and pathophysiology, which will permit biochemists and medicinal chemists to design novel medicines.
John Vane & Pedro Cuatrecasas
doi:10.1038/312303a0
References | PDF (431K)
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| | News and Views |  |
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| | Who will clone a chromosome? 306
The cloning of factor VIII, on which most haemophiliacs depend, is a technical triumph without parallel, but has left important questions unanswered. They rest for others.
John Maddox
doi:10.1038/312306a0
PDF (133K)
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| | Biotechnology: Clotting factor VIII cloned 307
George G. Brownlee & Charles Rizza
doi:10.1038/312307a0
PDF (135K)
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| | Astrophysics: Evolution of star−planet systems 307
Geoffrey Bath
doi:10.1038/312307b0
PDF (273K)
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| | Molecular biology: Multiple levels of gene control in eukaryotic cells 308
Geoffrey North
doi:10.1038/312308a0
References | PDF (299K)
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| | 100 years ago 309
doi:10.1038/312309a0
PDF (161K)
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| | Carbon cycle: Surprise from the shallows 310
M. Whitfield
doi:10.1038/312310a0
PDF (141K)
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| | Cell biology: A spectrum of spectrins 310
A.J. Baines
doi:10.1038/312310b0
References | PDF (392K)
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| | Devonian vertebrates from South America 311
doi:10.1038/312311a0
PDF (254K)
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| | Cell activation: The 'basic' connection 312
Walter F. Boron
doi:10.1038/312312a0
References | PDF (144K)
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| | Scientific Correspondence | |
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| | Territory, size and weight gain 313
R.K. BUTLIN
doi:10.1038/312313a0
References | PDF (144K)
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| | Pigeons, canaries and problem-solving 313
ROBERT EPSTEIN
doi:10.1038/312313b0
References | PDF (144K)
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| | DNA sequence selection by eye 313
M. G. BURDON
doi:10.1038/312313c0
References | PDF (144K)
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| | Transformation by the p21
ras
protein 314
R. F. NEWBOLD
doi:10.1038/312314a0
References | PDF (142K)
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| | The gyroscope test of relativity 314
B. M. BARKER & R. F. O'CONNELL
doi:10.1038/312314b0
References | PDF (142K)
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| | Mouse Ig sequence elements in Drosophila
314
La Jolla
doi:10.1038/312314c0
References | PDF (142K)
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| | Mouse Ig sequence elements in Drosophila
314
doi:10.1038/312314d0
References | PDF (142K)
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| | Review Article | |
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| | Inositol trisphosphate, a novel second messenger in cellular signal transduction 315
Michael J. Berridge & Robin F. Irvine
doi:10.1038/312315a0
Abstract & References | PDF (880K)
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| | Articles |  |
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| | Water column dissolution of aragonite in the Pacific Ocean 321
Robert H. Byrne, James G. Acker, Peter R. Betzer, Richard A. Feely & Marion H. Cates
doi:10.1038/312321a0
Abstract & References | PDF (872K)
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| | Characterization of the human factor VIII gene 326
Jane Gitschier, William I. Wood, Therese M. Goralka, Karen L. Wion, Ellson Y. Chen, Dennis H. Eaton, Gordon A. Vehar, Daniel J. Capon & Richard M. Lawn
doi:10.1038/312326a0
Abstract & References | PDF (748K)
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| | Expression of active human factor VIII from recombinant DNA clones 330
William I. Wood, Daniel J. Capon, Christian C. Simonsen, Dan L. Eaton, Jane Gitschier, Bruce Keyt, Peter H. Seeburg, Douglas H. Smith, Philip Hollingshead, Karen L. Wion, Eric Delwart, Edward G. D. Tuddenham, Gordon A. Vehar & Richard M. Lawn
doi:10.1038/312330a0
Abstract & References | PDF (1,024K)
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| | Structure of human factor VIII 337
Gordon A. Vehar, Bruce Keyt, Dan Eaton, Henry Rodriguez, Donogh P. O'Brien, Frances Rotblat, Herman Oppermann, Rodney Keck, William I. Wood, Richard N. Harkins, Edward G. D. Tuddenham, Richard M. Lawn & Daniel J. Capon
doi:10.1038/312337a0
Abstract & References | PDF (805K)
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| | Molecular cloning of a cDNA encoding human antihaemophilic factor 342
John J. Toole, John L. Knopf, John M. Wozney, Lisa A. Sultzman, Janet L. Buecker, Debra D. Pittman, Randal J. Kaufman, Eugene Brown, Charles Shoemaker, Elizabeth C. Orr, Godfrey W. Amphlett, W. Barry Foster, Mary Lou Coe, Gaylord J. Knutson, David N. Fass & Rodney M. Hewick
doi:10.1038/312342a0
Abstract & References | PDF (778K)
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| | Letters | |
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| | Cosmic-ray emission from Cygnus X-3 347
N. A. Porter
doi:10.1038/312347a0
First paragraph & References | PDF (270K)
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| | A disk origin for superhumps in Ursae Majoris variables 348
Keith Horne
doi:10.1038/312348a0
First paragraph & References | PDF (461K)
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| | Differentiation between 27Al nuclei in alums by Fourier transform pure nuclear quadrupole resonance 351
D. B. Zax, A. Bielecki, A. Pines & S. W. Sinton
doi:10.1038/312351a0
First paragraph & References | PDF (216K)
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| | Direct determination of strontium enrichment on grain boundaries in a garnet lherzolite xenolith by proton microprobe analysis 352
Donald G. Fraser, F. Watt, G. W. Grime & J. Takacs
doi:10.1038/312352a0
First paragraph & References | PDF (419K)
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| | Upwarp of anomalous asthenosphere beneath the Rio Grande rift 354
E. C. Parker, P. M. Davis, J. R. Evans, H. M. Iyer & K. H. Olsen
doi:10.1038/312354a0
First paragraph & References | PDF (361K)
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| | Enhanced preservation of marine-derived organic matter in Cenomanian black shales from the southern Angola Basin 356
P. A. Meyers, M. J. Leenheer, O. E. Kawka & T. W. Trull
doi:10.1038/312356a0
First paragraph & References | PDF (636K)
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| | A model of estuarine circulation in the Pliocene Mediterranean based on new ostracod evidence 359
Dick van Harten
doi:10.1038/312359a0
First paragraph & References | PDF (570K)
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| | Potassium-selective single channels in guard cell protoplasts of Vicia faba
361
J. I. Schroeder, R. Hedrich & J. M. Fernandez
doi:10.1038/312361a0
First paragraph & References | PDF (310K)
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| | Benzodiazepines antagonize cholecystokinin-induced activation of rat hippocampal neurones 363
Jacques Bradwejn & Claude de Montigny
doi:10.1038/312363a0
First paragraph & References | PDF (238K)
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| | Immunohistochemical localization of endogenous nerve growth factor 364
R. A. Rush
doi:10.1038/312364a0
First paragraph & References | PDF (940K)
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| | Aetiology of AIDS—antibodies to human T-cell leukaemia virus (type III) in haemophiliacs 367
L. W. Kitchen, F. Barin, J. L. Sullivan, M. F. McLane, D. B. Brettler, P. H. Levine & M. Essex
doi:10.1038/312367a0
First paragraph & References | PDF (506K)
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| | Significance of herpesvirus immediate early gene expression in cellular immunity to cytomegalovirus infection 369
Matthias J. Reddehase & Ulrich H. Koszinowski
doi:10.1038/312369a0
First paragraph & References | PDF (381K)
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| | Phorbol ester and diacylglycerol mimic growth factors in raising cytoplasmic pH 371
W. H. Moolenaar, L. G. J. Tertoolen & S. W. de Laat
doi:10.1038/312371a0
First paragraph & References | PDF (477K)
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| | Stepwise enzymatic dephosphorylation of inositol 1,4,5-trisphosphate to inositol in liver 374
Diane J. Storey, Stephen B. Shears, Christopher J. Kirk & Robert H. Michell
doi:10.1038/312374a0
First paragraph & References | PDF (345K)
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| | A developmental gene product of Bacillus subtilis homologous to the sigma factor of Escherichia coli
376
Patrick Stragier, Jean Bouvier, Céline Bonamy & Jekisiel Szulmajster
doi:10.1038/312376a0
First paragraph & References | PDF (436K)
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| | Erratum: New evidence that growth in 3T3 cell cultures is a diffusion-limited process 378
G. A. Dunn & G. W. Ireland
doi:10.1038/312378a0
PDF (229K)
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| | Matters Arising | |
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| | African marsupials—vicariance or dispersion? 379
J. J. JAEGER & M. MARTIN
doi:10.1038/312379a0
References | PDF (143K)
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| | African marsupials— vicariance or dispersion? (reply) 379
T. M. BOWN & E. L. SIMONS
doi:10.1038/312379b0
References | PDF (282K)
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| | Cometary showers and unseen solar companions 380
PAUL R. WEISSMAN
doi:10.1038/312380a0
References | PDF (142K)
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| | Cometary showers and unseen solar companions (reply) 380
RICHARD A. MULLER, PIET HUT, MARC DAVIS & WALTER ALVAREZ
doi:10.1038/312380b0
References | PDF (281K)
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| | Cometary showers and unseen solar companions (reply) 381
DANIEL P. WHITMIRE & ALBERT A. JACKSON IV
doi:10.1038/312381a0
References | PDF (143K)
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| | The maximum entropy method for data analysis 381
D. M. TITTERINGTON
doi:10.1038/312381b0
References | PDF (286K)
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| | The maximum entropy method for data analysis (reply) 382
JOHN SKILLING
doi:10.1038/312382a0
References | PDF (147K)
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| | Book Reviews | |
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| | Past probabilities 383
Patrick Rabbitt reviews Genius, Creativity & Leadership: Historiometric Inquiries
By
Dean Keith Simonton
doi:10.1038/312383a0
PDF (268K)
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| | Cue for cooperation 384
F.H. Bronson reviews Mammalian Semiochemistry: The Investigation of Chemical Signals Between Mammals
By
Eric S. Albone
doi:10.1038/312384a0
PDF (141K)
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| | SOM introduction 384
P.W. Hawkes reviews Theory and Practice of Scanning Optical Microscopy
By
Tony Wilson & Colin Sheppard
doi:10.1038/312384b0
PDF (278K)
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| | Flying tonight 385
P.A. Racey reviews Bats: A Natural History
By
John E. Hill & James D. Smith and The Lives of Bats
By
Wilfried Schober
doi:10.1038/312385a0
PDF (139K)
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| | Molecular orbitals: into the age of computer graphics 385
Jeremy K. Burdett reviews A Pictorial Approach to Molecular Structure and Reactivity
By
Robert F. Hout Jr, William J. Pietro & Warren J. Hehre
doi:10.1038/312385b0
PDF (139K)
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| | Developing theories of evolution 386
J.S. Jones reviews Mechanisms of Morphological Evolution: A Combined Genetic, Developmental and Ecological Approach
By
Wallace Arthur
doi:10.1038/312386a0
PDF (142K)
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| | In the soup 386
A. E. Walsby reviews The Ecology of Freshwater Phytoplankton
By
C. S. Reynolds
doi:10.1038/312386b0
PDF (142K)
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| | Books Received | |
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| | Books Received 387
doi:10.1038/312387a0
PDF (151K)
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| | Employment | |
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| | New skills for new technologies 388
In some areas — biotechnology being an exception — employers requiring graduate skills seem reluctant to take on candidates with higher degrees.
Richard Pearson
doi:10.1038/312388a0
PDF (133K)
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