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Microtubule assembly nucleated by isolated centrosomes

Nature volume 312, pages 232–237 (1984)Cite this article

Abstract

Microtubules are involved in the morphogenesis of most cells and are the structural basis of the mitotic spindle. We report here that purified centrosomes nucleate the assembly of microtubules with unusual dynamic properties. This may have important implications for the mechanism by which microtubule arrays are organized and stabilized in cells.

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Authors and Affiliations

  1. Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California, 94143, USA

    Tim Mitchison & Marc Kirschner

Authors
  1. Tim Mitchison
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  2. Marc Kirschner
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Mitchison, T., Kirschner, M. Microtubule assembly nucleated by isolated centrosomes. Nature 312, 232–237 (1984). https://doi.org/10.1038/312232a0

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  • DOI: https://doi.org/10.1038/312232a0

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