Abstract
By subtractive cDNA hybridizations, we have isolated a new species of T-cell receptor cDNA clone whose predicted amino acid sequence has homology to variable, constant, joining and diversity segments of immunoglobulins and T-cell receptors. The corresponding genomic sequence is also rearranged in several T-cell DNAs. The four potential N-linked glycosylation sites, frequency of expression and predicted molecular weight (27,800) of this molecule make it a likely candidate for the α-chain of the T-cell receptor. Expression data also indicate that this gene may be activated at a later stage of T-cell differentiation than the β-chain.
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Chien, Yh., Becker, D., Lindsten, T. et al. A third type of murine T-cell receptor gene. Nature 312, 31–35 (1984). https://doi.org/10.1038/312031a0
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DOI: https://doi.org/10.1038/312031a0
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