Nature 311, 29 - 33 (06 September 1984); doi:10.1038/311029a0

Molecular cloning of a new transforming gene from a chemically transformed human cell line

Colin S. Cooper^*, Morag Park^†, Donald G. Blair^†, Michael A. Tainsky^†, Kay Huebner^‡, Carlo M. Croce^‡ & George F. Vande Woude^§

^*Laboratory of Molecular Carcinogenesis, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
^†Laboratory of Molecular Oncology, National Cancer Institute, Frederick Cancer Research Facility, Frederick, Maryland 21701, USA
^‡The Wistar Institute, 36th and Spruce, Philadelphia, Pennsylvania 19104, USA
^§Basic Research Program, Litton Bionetics, Inc., Frederick, Maryland 21701, USA

Molecular cloning of the transforming gene from a chemically transformed human osteosarcoma-derived cell line enables the gene to be mapped to chromosome 7 (7p11.4−7qter) and by this criterion and by direct hybridization to be shown to be unrelated to known oncogenes.

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