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Article
Nature 310, 207-211 (19 July 1984) | doi:10.1038/310207a0; Accepted 1 May 1984
DNA sequence and expression of the B95-8 Epstein—Barr virus genome
R. Baer*, A. T. Bankier, M. D. Biggin, P. L. Deininger*, P. J. Farrell†, T. J. Gibson, G. Hatfull, G. S. Hudson, S. C. Satchwell, C. Séguin*, P. S. Tuffnell† & B. G. Barrell
- MRC Laboratory of Molecular Biology and †Ludwig Institute for Cancer Research, MRC Centre, Hills Road, Cambridge CB2 2QH, UK
- *Present addresses: Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA (R.B.); LSU Medical Center, 1901 Perdido St, New Orleans, Louisiana 70112, USA (P.L.D.); Cellular Regulation Section, Laboratory of Biochemistry, NCI, National Institutes of Health, Bethesda, Maryland 20205, USA (C.S.).
Abstract
The complete (172,282 base pairs) nucleotide sequence of the B95-8 strain of Epstein–Barr virus has been established using the dideoxynucleotide/M13 sequencing procedure. Many RNA polymerase II promoters have been mapped and the mRNAs from these promoters have been assigned to the latent or early/late productive virus cycles. Likely protein-coding regions have been identified and three of these have been shown to encode a ribonucleotide reductase, a DNA polymerase and two surface glycoproteins.
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