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Article
Nature 308, 705-709 (19 April 1984) | doi:10.1038/308705a0; Accepted 25 February 1984
Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats
Hartwig Schmale & Dietmar Richter
- Abteilung Zellbiochemie, Institut für Physiologische Chemie, Universität Hamburg, Martinistrasse 52, D-2000 Hamburg 20, FRG
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Abstract
In rats with hereditary hypothalamic diabetes insipidus (Brattleboro rats) the gene for the vasopressin precursor lacks a single G residue in the protein-coding region. The mutation gives rise to an open reading frame predicting a hormone precursor having a different C-terminus.
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